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Surface hydrolysis of fibrous poly(ε-caprolactone) scaffolds for enhanced osteoblast adhesion and proliferation

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Abstract

A procedure for the surface hydrolysis of an electrospun poly(ε-caprolactone) (PCL) fibrous scaffold was developed to enhance the adhesion and proliferation of osteoblasts. The surface hydrolysis of fibrous scaffolds was performed using NaOH treatment for the formation of carboxyl groups on the fiber surfaces. The hydrolysis process did not induce deformation of the fibers, and the fibers retained their diameter. The cell seeding density on the NaOH-treated PCL fibrous scaffolds was more pronounced than on the non-treated PCL fibers used as a control. The alkaline phosphatase activity, osteocalcin and a mineralization assay strongly supported that the surface-hydrolyzed PCL fibrous scaffolds provided more favorable environments for the proliferation and functions of osteoblasts compared to the non-treated PCL fibrous scaffolds use as a control.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Kangnam St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 137-701, Seoul, Korea

    Jeong Soo Park & Jung-Man Kim

  2. Department of Nano Technology, Advanced Nano Materials Research Team, Daegu Gyeongbuk Institute of Science & Technology, 704-230, Daegu, Korea

    Sung Jun Lee & Se Geun Lee

  3. Hybrid Materials Solution National Core Research Center (NCRC), Pusan National University, 609-735, Busan, Korea

    Young-Keun Jeong

  4. Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, 153-801, Seoul, Korea

    Sung Eun Kim & Sang Cheon Lee

Authors
  1. Jeong Soo Park
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  2. Jung-Man Kim
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  3. Sung Jun Lee
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  4. Se Geun Lee
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  5. Young-Keun Jeong
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  6. Sung Eun Kim
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  7. Sang Cheon Lee
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Correspondence to Jung-Man Kim or Sang Cheon Lee.

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Park, J.S., Kim, JM., Lee, S.J. et al. Surface hydrolysis of fibrous poly(ε-caprolactone) scaffolds for enhanced osteoblast adhesion and proliferation. Macromol. Res. 15, 424–429 (2007). https://doi.org/10.1007/BF03218809

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  • DOI: https://doi.org/10.1007/BF03218809

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