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Polymorphisms of alcohol metabolizing enzyme and cytochrome P4502E1 genes in mongolian population

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Abstract

Although the genetic polymorphism of the alcohol-metabolizing enzymes was extensively studied at the molecular level by many investigators, the genetic polymorphism studies for ethanolmetabolizing enzymes in Mongolians are very rare. The present study was therefore performed to determine the genetic distribution of various forms of alcohol-metabolizing enzymes such as alcohol dehydrogenase 2 (ADH2, currently accepted nomenclature ADH1B), ADH3 (ADH1C), aldehyde dehydrogenase 2 (ALDH2) and cytochrome P4502E1 (CYP2E1) in 300 healthy Mongolian males. Genetic polymorphisms were determined by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods. The allele frequencies ofADH2 *1 andADH2 *2 were 0.24 and 0.76;ADH3 *1 andADH3 *2 were 0.92 and 0.08;ALDH2 *1 andALDH2 *2 were 0.96 and 0.04; andCYP2E1 *C andCYP2E1 *D were 0.15 and 0.85, respectively. Compared to the results reported by other investigators, the allele frequencies ofALDH2 *2 andCYP2E1 *C among Mongolian subjects were much lower than among East Asians (Korean, Japanese, and/or Han-Chinese), while those ofADH2 andADH3 were more similar. Interestingly, this study shows that the ineffectiveALDH2 gene (ALDH2*2 allele) among Mongolians is not as common as among East Asians.

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Authors and Affiliations

  1. Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Incheon, Korea

    Ki-Woong Kim, Kyung-Hwa Heo & Yong Lim Won

  2. Reproductive Health United Nations Population Fund Country Office in Mongolia, UNFPA, Mongolia

    Bayanbileg Shinetugs

  3. Health Science of University of Mongolia, Mongolia

    Tserenkhuu Lkhagwasuren

  4. Department of Chemistry, Soonchunhyang University, Asan, Korea

    Sung Keun Chang

  5. Department of Biology, Chungnam National University, Daejeon, Korea

    Sang-Gi Paik

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  1. Ki-Woong Kim
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  2. Bayanbileg Shinetugs
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  3. Kyung-Hwa Heo
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  4. Yong Lim Won
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Correspondence to Ki-Woong Kim or Sang-Gi Paik.

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Kim, KW., Shinetugs, B., Heo, KH. et al. Polymorphisms of alcohol metabolizing enzyme and cytochrome P4502E1 genes in mongolian population. Genes & Genomics 31, 377–385 (2009). https://doi.org/10.1007/BF03191256

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  • DOI: https://doi.org/10.1007/BF03191256

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