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The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism

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Summary

Celery (Apium graveolens) and parsley (Petroselinum sativum), plants used worldwide in human nutrition, are the natural sources of methoxsalen. In this study we investigated the effect of mice pretreatment with juices of this plants on the hypnotic action of pentobarbital and analgesic action of paracetamol and aminopyrine, the drugs involving cytochrome P450 superfamily in their metabolism. In mice pretreated with celery and parsley juices a prolonged action of pentobarbital with respect to control was observed, statistical significance being attained only with parsley-pretreated animals. Both pretreatments increased and prolonged the analgesic action of aminopyrine and paracetamol, pretreatment with parsley being again more effective. Celery and parsley juices given to animals two hours before their decapitation caused a significant decrease of cytochrome P450 in the liver homogenate as compared to control.

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Authors and Affiliations

  1. Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, Hajduk Veljikova 3, 21000, Novi Sad, Yugoslavia

    V. Jakovljevic & A. Raskovic

  2. Institute of Chemistry, Faculty of Sciences, Novi Sad, Yugoslavia

    M. Popovic

  3. Institute of Field Crops and Hop, Backi Petrovac, Yugoslavia

    J. Sabo

Authors
  1. V. Jakovljevic
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  2. A. Raskovic
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  3. M. Popovic
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  4. J. Sabo
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Jakovljevic, V., Raskovic, A., Popovic, M. et al. The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism. Eur. J. Drug Metab. Pharmacokinet. 27, 153–156 (2002). https://doi.org/10.1007/BF03190450

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  • DOI: https://doi.org/10.1007/BF03190450

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