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Natural products in plant protection

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Abstract

Natural products can be used to control pests and diseases in crops. These products include anorganic compounds, but also a variety of plant extracts. In the beginning of this century active microbial extracts were discovered as well. Synthetic crop protection chemicals were developed from about 1940 onwards and sustained progress in modern agriculture. The first generation chemicals have aspecific modes of toxic action and are in many instances deleterious to the environment. The second generation chemicals have specific modes of action and meet modern environmental requirements. A disadvantage of these chemicals is the potency of target organisms to acquire resistance. This condition urged agrochemical industry to develop chemicals with new modes of action. Such chemicals can be developed by using natural bioactive products as leads in synthesis programmes.

This paper decribes the progress that was made in the development of natural bioactive compounds in pest and disease control.

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References

  • Ames, B.N., Profet, M. & Gold, L.S., 1990. Nature’s chemicals and synthetic chemicals: comparative toxicology. Proceedings of the National Academy of Sciences USA 87: 7782–7786.

    Article  CAS  Google Scholar 

  • Ammermann, E., Lorenz, G., Schelberger, K., Wenderoth, B., Sauter, H. & Rentzea, C., 1992. BAS 490 F — A broad spectrum fungicide with a new mode of action. Brighton Crop Protection Conference, Pests and Diseases 1992 1: 403–410.

    Google Scholar 

  • Ammermann, E. & Scherer, D.I.M., 1993. Plant invigourating and antifungal capacities of polygonum extract — a case of synergism? Pesticide Science: in press.

  • Anke, T. & Steglich, W., 1989. β-Methoxyacrylate antibiotics: from biological activity to synthetic analogues. In: Schlunegger, U.P. (Ed.), Biologically active molecules. Springer Verlag, Berlin, Germany, p. 9–25.

    Google Scholar 

  • Anonymous, 1991. Meerjarenplan Gewasbescherming, SDU Uitgeverij, The Hague, the Netherlands. 298 pp.

  • Arima, K.H., Imanaka, M., Kousaka, A., Fukuda, A. & Tamura, G., 1965. Studies on pyrrolnitrin. K: Isolation and properties of pyrrolnitrin, Journal of Antibiotics 18: 201–204.

    PubMed  CAS  Google Scholar 

  • Beautement, K., Clough, J.M., De Fraine, P.J. & Godfrey, C.R.A., 1991. Fungicidal β-methoxyacrylates: from natural products to novel synthetic agricultural fungicides. Pesticide Science 31: 499–519.

    Article  CAS  Google Scholar 

  • Becker, W.F., von Jagow, G., Anke, T. & Steglich, W., 1981. Oudemansin, strobilurin A, strobilurin B and myxothiazole: new inhibitors of the bcl segment of the respiratory chain with an E-β-methoxyacrylate system as common structural element. FEBS Letters 132: 329–333.

    Article  PubMed  CAS  Google Scholar 

  • Bell, E.A., Fellows, L.E. & Simmonds, M.S.J., 1990. Natural products from plants for the control of insect pests. In: Hodgson, E. & Kuhr, R.J. (Eds), Safer insecticides, development and use. Marcel Dekker, New York, USA, p. 337–350.

    Google Scholar 

  • Bennett, J.W. & Bentley, R., 1989. What’s in a name? Microbial secondary metabolism. Advances in Applied Microbiol 34: 1–28.

    Article  CAS  Google Scholar 

  • Berdy, J., 1980. CRC handbook of antibiotic compounds. CRC Press, Boca Raton, Florida, USA.

    Google Scholar 

  • Cremlyn, R.J.W., 1991. Agrochemicals: preparation and mode of action. John Wiley, Chichester, UK. 396 pp.

    Google Scholar 

  • Cutler, H.G., 1988. Biologically active natural products. Potential use in agriculture. American Chemical Society, Washington, DC, USA, 483 pp.

    Google Scholar 

  • Davies, J.H., 1985. The pyrethroids, a historical introduction. In: Leahey, J.P. (Ed.), The pyrethroid insecticides. Taylor and Francis, London, UK. p. 1–41.

    Google Scholar 

  • Défago, G. & Haas, D., 1990. Pseudomonads as antagonists of soilborne plant pathogens: modes of action and genetic analysis. In: Bollag, J.-M. & Stotzky, G. (Eds), Soil Biochemistry, Volume 6. Marcel Dekker Inc, New York, USA. p. 249–292.

    Google Scholar 

  • Delp, C.J., 1988. Fungicide resistance in North America. APS Press, St. Paul, Minnesota, USA, 133 pp.

    Google Scholar 

  • Edwards, C.A. & Stinner, B.R., 1990. The use of innovative agricultural practices in a farm systems context for pest control in the 1990s. Brighton Crop Protection Conference, Pests and Diseases 1990 2: 679–684.

    Google Scholar 

  • Elliot, M., 1989. The pyrethroids: early discovery, recent advances and the future. Pesticide Science 27: 337–351.

    Article  Google Scholar 

  • Engel, J.F., Harnish, W.N. & Staetz, C.A., 1990. Challenges: the industrial viewpoint. In: Hodgson, E. & Kuhr, R. (Eds), Safer insecticides, development and use. Marcel Dekker Inc, New York, USA, p. 551–573.

    Google Scholar 

  • Entwistle, P.F., Cory, J.S., Bailey, M.J. & Higgs, S., 1993.Baeillus thuringiensis, An environmental biopesticide: Theory and Practice. John Wiley & Sons, Chichester, UK, 311 pp.

    Google Scholar 

  • Evans, P.D., 1985. Approaches to new leads for insecticides. In: Keyserlingk, H.C. von, Jaeger, A. & Szczepanski, Ch. von (Eds), Approaches to new leads for insecticides. Springer Verlag, Berlin, Germany, p. 117–131.

    Google Scholar 

  • Ford, M.G., Greenwood, R., Turner, C.H., Hudson, B. & Livingstone, D.J., 1989. The structure/activity relationships of pyrethroid insecticides. I. A novel approach based upon the use of multivariate QSAR and computational chemistry. Pesticide Science 27: 305–326.

    Article  CAS  Google Scholar 

  • Gehmann, K., Nyfeler, R., Leadbeater, A.J., Nevill, D. & Sozzi, D., 1990. CGA 173506: A new phenylpyrrole fungicide for broad-spectrum disease control. Brighton Crop Protection Conference, Pests and Diseases 1990 2: 399–406.

    Google Scholar 

  • Georghiou, G.P. & Lagunes, A., 1988. The occurence of resistance to pesticides: cases of resistance reported worldwide trough 1988. F.A.O., Rome, Italy, 325 pp.

    Google Scholar 

  • Gillespie, A.T. & Claydon, N., 1989. The use of entomogenous fungi for pest control and the role of toxins in pathogenisis. Pesticide Science 27: 203–215.

    Article  CAS  Google Scholar 

  • Godwin, J.R., Anthony, V.M., Clough, J.M. & Godfrey, C.R.A., 1992. ICIA5504: A novel broad spectrum, systemic β-methoxyacrylate fungicide. Brighton Crop Protection Conference, Pests and Diseases 1992 1: 435–443.

    Google Scholar 

  • Grabski, G.C. & Mendgen, K., 1986. Die Parasitierung des Bohnenrostes Uromyces appendiculatus var appendiculatus durch den Hyperparasiten Verticillium lecanii: Untersuchungen zur Wirt Erkennung, Penetration und Abbau der Rostpilzsporen. Journal Phytopathology 115: 116–123.

    Article  Google Scholar 

  • Gutterson, N., 1990. Microbial fungicides: recent approaches to elucidating mechanisms. Critical Reviews in Biotechnology 10: 69–91.

    Article  Google Scholar 

  • Hain, R., Reif, H.-J., Krause, E., Langebartels, R., Kindl, H., Vornam, B., Wiese, W., Schmelzer, E., Schreier, P.H., Stoecker, R.H. & Stenzel, K., 1993. Disease resistance results from foreign phytoalexin expression in a novel plant. Nature 361: 153–156.

    Article  PubMed  CAS  Google Scholar 

  • Hammer, P.E. & Evensen, K.B., 1993. Post harvest control of Botrytis cinerea on cut rose flowers with pyrrolnitrin. Plant Disease 77: 283–286.

    CAS  Google Scholar 

  • Isono, K., 1990. Antibiotics as non pollution agricultural pesticides. Comments on Agricultural and Food Chemistry 2: 123–142.

    CAS  Google Scholar 

  • Kidd, H. & James, D.R. 1991. The agròchemicals handbook, 3rd ed., Royal Society of Chemistry, Cambridge, UK, 1500 pp.

    Google Scholar 

  • Lisansky, S.G. & Coombs, J., 1992. Technical improvements to biopesticides. Brighton Crop Protection Conference, Pests and Diseases 1992 1: 345–350.

    Google Scholar 

  • Mansfield, R.W. & Wiggins, T.E., 1990. Photoaffinity labelling of the β-methoxyacrylate binding site in bovine heart mitochondrial cytochrome bcl complex. Biochimica et Biophysica Acta 1015: 109–115.

    Article  PubMed  CAS  Google Scholar 

  • Marco, G.J., Hollingworth, R.M. & Plimmer, J.R., 1991. Regulation of agrochemicals, a driving force in their evolution. American Chemical Society, Washington, DC, USA. 188 pp.

    Google Scholar 

  • Marrone, P.G. & Macintosh, S.C., 1993. Resistance to Bacillus thuringiensis and resistance management. In: Entwistle, P.F., Cory, J.S., Bailey, M.J. & Higgs, S. (Eds.), Bacillus thuringiensis, An environmental biopesticide: Theory and Practice. John Wiley & Sons, Chichester, UK. p. 221–235.

    Google Scholar 

  • Marston, A. & Hostettman, K., 1987. Antifungal, molluscicidal and cytotoxic compounds from plants used in traditional medicine. In: Hostettman, K., Lea, P.J. (Eds.), Biologically active natural products. Clarendon Press, Oxford, UK, p. 65–84.

    Google Scholar 

  • McCallan, S.E.A., 1969. History of fungicides. In: Torgeson, D.C. (Ed.), Fungicides, an advanced treatise, Volume 1. Academic Press Inc, New York, USA, p. 1–38.

    Google Scholar 

  • McDonald, D., 1991. Biopesticides pesticides with a bright future? International Pest Control 33: 33–35.

    Google Scholar 

  • Nakamura, H., Shiomi, K., Iinuma, H., Naganawa, H., Obata, T., Takeuchi, T., Umezawa, H., Takeuchi, Y. & Iitaka, Y., 1987. Isolation and characterization of a new antibiotic, dioxapyrrolomycin, related to pyrrolomycins. Journal of Antibiotics 40: 899–903.

    PubMed  CAS  Google Scholar 

  • Nevill, D., Nyfeler, R. & Sozzi, D., 1988. CGA 142705: A novel fungicide for seed treatment. Brighton Crop Protection Conference, Pests and Diseases 1988 1: 65–72.

    Google Scholar 

  • Nogami, T., Shigihara, Y., Matsuda, N., Takahashi, Y., Naganawa, H., Nakamura, H., Hamada, M., Muraoka, Y., Takita, T., Iitaka, Y. & Takeuchi, T. 1990. Neopyrrolomycin, a new chlorinated phenylpyrrole antibiotic. Journal of Antibiotics 43: 1192–1194.

    PubMed  CAS  Google Scholar 

  • Nyfeler, R. & Ackermann, P., 1991. Phenylpyrroles, a new class of agricultural fungicides related to the natural antibiotic pyrrolnitrin. Abstracts of papers American Chemical Society 201: AGRO 116.

    Google Scholar 

  • Nyfeler, R., Egli, Th. & Nevill, D., 1990. Phenylpyrroles, a new class of agricultural fungicides related to the natural antibiotic pyrrolnitrin. Proceedings IUPAC Hamburg, Germany. p. 219.

    Google Scholar 

  • Pee, K.-H. van & Lingens, F., 1988. Purification of bromoperoxidase from Pseudomonas aureofaciens. Journal of Bacteriology 161: 1171–1175.

    Google Scholar 

  • Rathmell, W.G., 1984. The discovery of new methods of chemical disease control: current developments, future prospects and the role of biochemical and physiological research. Advances in Plant Pathology 2: 259–288.

    CAS  Google Scholar 

  • Roberts, S.M., 1989. From dregs to drugs: The discovery of new chemotherapeutic agents. Pesticide Science 27: 111–116.

    Article  CAS  Google Scholar 

  • Simpson, T.J., Dillon, M.P. & Donovan, T.M., 1991. Synthetic and mechanistic studies on fungal metabolic pathways: A guide to fungicide design. Pesticide Science 31: 539–554.

    Article  CAS  Google Scholar 

  • Sivan, A. & Chet, I., 1992. Microbial control of plant diseases. In: Mitchel, R. (Ed.), Environmental microbiology. John Wiley, New York, USA. p. 335–354.

    Google Scholar 

  • Tawara, S., Matsumoto, S., Hirose, T., Matsumoto, Y., Nakamoto, S., Mitsuno, N. & Kamimura, T., 1989. In vitro antifungal synergism between pyrrolnitrin and clotrimazole. Japanese Journal of Medical Mycology 30: 202–210.

    Google Scholar 

  • Thomashow, L.S. & Weller, D.M., 1991. Role of antibiotics and siderophores in biocontrol of take all disease of wheat. In: Keister, D.L. & Cregan, P.B. (Eds), Beltsville Symposia in Agricultural Research 14: 245–251.

  • Whipps, J.M. & Lumsden, R.D., 1991. Biological control of Pythium species. Biocontrol Science and Technology 1: 75–90.

    Article  Google Scholar 

  • White, J.G., Linfield, C.A., Lahdenpera, M.-L. & Uoti, J., 1990. Mycostop — a novel biofungicide based on Streptomyces griseovirides. Brighton Crop Protection Conference, Pests and Diseases 1990 1: 221–226.

    Google Scholar 

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Jespers, A.B.K., De Waard, M.A. Natural products in plant protection. Neth. J. Pl. Path. 99 (Suppl 3), 109–117 (1993). https://doi.org/10.1007/BF03041401

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