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The hippocampus and stress induced 17-OHCS elevations

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Abstract

The physiologic contribution of the limbic brain to emotionally induced stress is still poorly understood. The present study is designed to more specifically evaluate the role of the hippocampus in stress induced plasma 17-OHCS elevations. The conditional reflex to a sequential presentation of tone and shock was used as the stress agent in adult mongrel dogs. Plasma 17-OHCS levels were determined by the Porter-Silber method. Control and stress levels of 17-OHCS were determined before and after unilateral (left) hippocampectomy, and subsequent contralateral (right) hippocampectomy. A unilateral posterior hippocampal lesion partially attenuated (20%) the normal 17-OHCS stress response. In contrast to unilateral lesions, equivalent bilateral posterior hippocampal lesions abolished the normal 17-OHCS stress response. These observations support the thesis that the elevated 17-OHCS levels in response to the conditioning paradigm is dependent on the hippocampus. Furthermore, it is dependent upon the continuity of the hippocampal circuit and not upon the volumetric steroid binding capacity of the hippocampus. These studies also suggest that a unilaterally functioning hippocampus may be adequate to meet the physiologic needs of stress, as reflected by the 17-OHCS response. Presented at the 1978 meeting of the Pavlovian Society, St. Petersburg, Florida.

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References

  • Andy, O. J., Webster, C. L., Mukawa, J. and Bonn, P.: Electro-physiological comparisons of the dorsal and ventral hippocampus. InPhysiologie De L’Hippocampe, Paris, Du Centre National De La Recherche Scientifique, 1962, pp. 24–26.

    Google Scholar 

  • Andy, O. J. and Mitchell, J.: The role of Limbic structures in learned behavior. Surg. Forum11, 383–385, 1960.

    PubMed  Google Scholar 

  • Andy, O. J., Chinn, R. M. and Bonn, P.: Effect of hippocampal system after-discharges upon learned behavior. Surg. Forum8, 546–549, 1958.

    Google Scholar 

  • Bohus, G., Nyakas, C. and Lissak, K.: Involvement of suprahypothalamic structures in the hormonal feedback action of corticosteroids. Acta Physiological Academiae Scientiarum Hungaricae34: 1–8, 1968.

    Google Scholar 

  • Bouille, C. and Bayle, J. D.: Comparison between hypothalamic multiple-unit activity and corticotropic function after bilateral destruction of the hippocampus. Neuroendocrinology25, 303–309, 1978.

    Article  PubMed  Google Scholar 

  • Bush, I. E.: Chemical and biological factors in the activity of adrenocortical steroids. Pharmacol. Rev.14, 317–445, 1962.

    PubMed  Google Scholar 

  • Casady, R. L. and Taylor, A. N.: Effect of electrical stimulation of the hippocampus upon corticosteroid levels in the freely-behaving, non-stressed rat. Neuroendocrinology20, 68–78, 1976.

    Article  PubMed  Google Scholar 

  • Chow, Kao, Liang: Effect of local electrographic after-discharges on visual learning and retention in monkey. J. Neurophysiol.24, 391–400, 1961.

    PubMed  Google Scholar 

  • Conforti, N. and Feldman, S.: Feedback effects of dexamethasone on adrenocortical response in rats with fornix section. Hormone Res.7, 56–60, 1976.

    Article  PubMed  Google Scholar 

  • Conforti, N. and Feldman, S.: Effects of dorsal fornix section and hippocampectomy on adrenocortical responses to sensory stimulation in the rat. Neuroendocrinology22, 1–7, 1976.

    Article  PubMed  Google Scholar 

  • Coover, G. D., Goldman, L. and Levine, S.: Plasma corticosterone levels during extinction of a leverpress response in hippocampectomized rats. Physiol. Behav.7, 727–732, 1971.

    Article  PubMed  Google Scholar 

  • Dupont, A., Bastarache, E., Endroczi, E. and Fortier C.: Effect of hippocampal stimulation on the plasma thyrotropin (THS) and corticosterone response to acute cold exposure in the rat. Can. J. Physiol. Pharmacol.50, 364–367, 1972.

    Article  PubMed  Google Scholar 

  • Ely, D. L., Greene, E. G. and Henry, J. P.: Effects of hippocampal lesion on cardiovascular, adrenocortical and behavioral response patterns in mice. Physiol. Behav.18, 1075–1083, 1977.

    Article  PubMed  Google Scholar 

  • Endroczi, E. and Lissak, K.: Interrelations between paleocortical activity and pituitary-adrenocortical function. Acta Physiol. Acad. Sci. Hung.21, 257–263, 1962.

    Google Scholar 

  • Endroczi, E. and Lissak, K., Bohus B. and Kovacs S.: The inhibitory influence of archicortical structures on pituitary/adrenal function. Acta Physiol. Acad. Sci. Hung.16, 17–22, 1959.

    Google Scholar 

  • Feldman, S., Conforti, N. and Chowers, I.: Inhibition of adrenocortical responses following sciatic nerve stimulation in rats with medial forebrain bundle and mammillary peduncular lesions Isr. J. Med. Sci.11, 493–495, 1975a.

    Google Scholar 

  • Feldman, S., Conforti, N. and Chowers, I.: Adrenocortical response following sciatic nerve stimulation in rats with partial hypothalamic deafferentations. Acta Endocr. Copenhagen80, 625–629, 1975b.

    Google Scholar 

  • Feldman, S., Conforti, N. and Chowers, I.: Subcortical pathways involved in the mediation of adrenocortical responses following sciatic nerve stimulation. Neuroendocrinology18, 359–365, 1975c.

    Article  Google Scholar 

  • Fendler, K., Karmos, G. and Teledgy, C.: The effect of hippocampal lesion on pituitary-adrenal function. Acta Physiol. Acad. Sci. Hung.20, 293–297, 1961.

    PubMed  Google Scholar 

  • Iuvone, P. M. and VanHartesveldt, C.: Locomotor activity and plasma corticosterone in rats with hippocampal lesions. Behav. Biol.16,(4): 515–520, 1976.

    Article  PubMed  Google Scholar 

  • Jackson, W. J. and Ragestein, Q. R.: Hippocampectomy in Rhesus monkeys: effects on plasma cortisol during two stressful conditions. Paper presented at the Society for Neuroscience Fourth Annual Meeting, St. Louis, October, 1974.

  • Kawakami, M., Seto, K., Terasawa, E.,et al.: Influence of electrical stimulation and lesion in limbic structure upon biosynthesis of adrenocorticoid in the rabbit. Neuroendocrinology,3, 337–348, 1968a.

    Article  PubMed  Google Scholar 

  • Kawakami, M., Seto, K. and Yoshida, K.: Influence of corticosterone implanation in limbic structure upon biosynthesis of adrenocortical steroid. Neuroendocrinology3, 349–354, 1968b.

    Article  PubMed  Google Scholar 

  • Kearly, R. C., Van Hartesveldt, C., Woodruff, M. L.: Behavioral and hormonal effects of hippocampal lesions on male and female rats. Physiol. Psychol.2, 187–196, 1974.

    Google Scholar 

  • Kim, C. and Kim, C. U.: Effect of partial hippocampal resection on stress mechanism in rats. Am. J. Physiol.201, 337–340, 1961.

    PubMed  Google Scholar 

  • Knigge, K.M.: Feedback mechanisms in neural control of adenohypophyseal function: Effect of steroids implanted in amygdala and hippocampus.Abstracts of the Second International Congress on Hormonal Steroids, Excerpta Medica International Congress Series No. 111. 208, 1966.

  • Knizley, H., Jr.: The hippocampus and septal area as primary target sites for corticosterone. J. Neurochem.19, 2727–2745, 1972.

    Article  Google Scholar 

  • Lanier, L. P., Van Hartesveldt, C., Weis, B., Isaacson, R. L.: Effects of differential hippocampal damage upon rhythmic and stress-induced corticosterone secretion in the rat. Neuroendocrinology18, (2): 154–160, 1975.

    Article  PubMed  Google Scholar 

  • Lengvari, I. and Halasz, B.: Evidence for a diurnal fluctuation in plasma corticosterone levels after fornix transection in the rat. Neuroendocrinology11, 191–196, 1973.

    Article  PubMed  Google Scholar 

  • MacLean, P.D.: An ongoing analysis of hippocampal inputs and outputs: Microelectrode and neuroanatomical findings in squirrel monkeys.In Isaacson, R.L. and Pribram, K.H. (eds.):The Hippocampus. New York, Plenum Press, 1975, pp. 177–206.

    Google Scholar 

  • Mason, J. W.: The central nervous regulation of ACTH secretion.In Jasper, H.H., Proctor, L. D., Knighton, R. S., Noshay, W. C. and Costello, R. T. (eds.):Reticular Formation of the Brain, Boston, Little Brown, 1957, pp. 645–670.

    Google Scholar 

  • Mason, J.W.: Plasma 17-hydroxycorticosteroid levels during electrical stimulation of the amygdaloid complex in conscious monkeys. Am. J. Physiol.196, 44–48, 1959.

    PubMed  Google Scholar 

  • McEwen, B. S., Gerlach, J. L. and Micco, D. J.: Putative glucocorticoid receptors in hippocampus and other regions of the rat brain.In Isaacson, R. L. and Pribram, K. H. (eds.):The Hippocampus. New York, Plenum Press, 1975, pp. 285–314.

    Google Scholar 

  • Moberg, G. P., Scapgnini, U., De Groot, J., Ganong, W. F.: Effect of sectioning the fornix on diurnal fluctuation in plasma corticosterone levels in the rat. Neuroendocrinology7, 11–15, 1971.

    Article  PubMed  Google Scholar 

  • Nakadate, G. and De Groot, J.: Fornix transection and adrenocortical function in rats. Anat. Rec.145, 338, 1963.

    Google Scholar 

  • Okinaka, S.: Die regulation der hypophysen-nebennierenfunktion durch das limbic-system und den mittelhirnanteil der formatio reticularis. Acta Neuroveg.23, 18–20, 1962.

    Google Scholar 

  • Porter, R. W.: The central nervous system and stressinduced eosinopenia. Recent Prog. Horm. Res.10, 1–27, 1954.

    Google Scholar 

  • Pribram, K. H. and MacLean, P. D.: Neuronographic analysis of medial and basal cerebral cortex, II. Monkey. J. Neurophysiol.16, 324–340, 1953.

    Google Scholar 

  • Raisman, G.: Some aspects of the neural connections of the hypothalamus.In Martini, L., Motta, M. and Fraschini, F.,The Hypothalamus. New York, Academic Press, 1970, pp. 1–15.

    Google Scholar 

  • Raisman, G., Cowan, W. M. and Powell, T. P. S.: An experimental analysis of the efferent projection of the hippocampus. Brain89, 83–108, 1966.

    Article  PubMed  Google Scholar 

  • Raisman, G. and Field, P. M.: Anatomical considerations relevant to the interpretation of neuroendocrine experiments.In Martini and Ganong,Frontiers in Neuroendocrinology, New York, Oxford Univ. Press, 1971, pp. 3–44.

    Google Scholar 

  • Rubin, R. T., Mandell, A. J. and Crandall, P. H.: Corticosteroid responses to limbic stimulation in man: Localization of stimulus sites. Science153, 767–768, 1966.

    Article  PubMed  Google Scholar 

  • Siegel, A. and Edinger, H.: Functional aspects of the hippocampal-septal axis.In DeFrance, J. F. (ed.):The Septal Nuclei. New York, Plenum Press, 1976, pp. 241–250.

    Google Scholar 

  • Slusher, M. A.: Effects of cortisol implants in brain stem and ventral hippocampus on diurnal corticosteroid levels. Exp. Brain Res.1, 184–194, 1966.

    Article  PubMed  Google Scholar 

  • Slusher, M. A. and Hyde, J. F.: Effects of Limbic stimulation on release of corticosteroids into the adrenal venous effluent of the cat. Endocrinology,69, 1080–1084, 1961.

    Article  PubMed  Google Scholar 

  • Wilson, M. and Critchlow, V.: Effect of fornix transection or hippocampectomy on rhythmic pituitaryadrenal function in the rat. Neuroendocrinology,13, 29–40, 1973.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Departments of Anatomy, Neurosurgery and Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi

    Ben R. Clower, O. J. Andy, M. Montalvo & D. Peeler

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  1. Ben R. Clower
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  2. O. J. Andy
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  3. M. Montalvo
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  4. D. Peeler
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Clower, B.R., Andy, O.J., Montalvo, M. et al. The hippocampus and stress induced 17-OHCS elevations. Pav. J. Biol. Sci. 14, 86–92 (1979). https://doi.org/10.1007/BF03001823

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