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Preclinical studies on [11C]MPDX for mapping adenosine A1 receptors by positron emission tomography

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Abstract

In previousin vivo studies with mice, rats and cats, we have demonstrated that [11C]MPDX ([1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine) is a potential radioligand for mapping adenosine A1 receptors of the brain by positron emission tomography (PET). In the present study, we performed a preclinical study. The radiation absorbed-dose by [11C]MPDX in humans estimated from the tissue distribution in mice was low enough for clinical use, and the acute toxicity and mutagenicity of MPDX were not found. The monkey brain was clearly visualized by PET with [11C]MPDX. We have concluded that [11C]MPDX is suitable for mapping adenosine A1 receptors in the human brain by PET.

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Author notes

  1. Shinichi Wakabayashi

    Present address: Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan

  2. Michio Senda

    Present address: Institute of Biomedical Research and Innovation, Kobe, Japan

Authors and Affiliations

  1. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Nakacho, Itabashi-ku, 173-0022, Tokyo, Japan

    Kiichi Ishiwata Ph.D., Yuichi Kimura, Keiichi Oda, Kazunori Kawamura, Kenji Ishii & Michio Senda

  2. Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan

    Tadashi Nariai

  3. Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., Kyowa, Japan

    Junichi Shimada

Authors
  1. Kiichi Ishiwata Ph.D.
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  2. Tadashi Nariai
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  3. Yuichi Kimura
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  4. Keiichi Oda
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  5. Kazunori Kawamura
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  6. Kenji Ishii
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  8. Shinichi Wakabayashi
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  9. Junichi Shimada
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Correspondence to Kiichi Ishiwata Ph.D..

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Ishiwata, K., Nariai, T., Kimura, Y. et al. Preclinical studies on [11C]MPDX for mapping adenosine A1 receptors by positron emission tomography. Ann Nucl Med 16, 377–382 (2002). https://doi.org/10.1007/BF02990074

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  • DOI: https://doi.org/10.1007/BF02990074

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