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Gastric carcinogenesis: Diet as a causative factor

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Abstract

Gastric cancer is a very typical cancer related to life styles, including nutrition and dietary conditions. Cigarette smoking has also been pointed out as an enhancing factor in gastric cancer development. Improvement of dietary conditions, regular dietary habits including lower salt, nitrite and nitrate intake and balanced nutritious food may be factors suppressing the incidence of gastric cancer. At the same time, advances in technology for early diagnosis and early surgical treatment have elevated the cure rate of gastric cancers. From both primary and secondary cancer prevention aspects, gastric cancer is now a conquerable disease.

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References

  1. International Agency for Research on Cancer, Biennial Report, Lyon, IARC (1986–1987).

  2. Haenszel W, Kurihara M: Studies of Japanese migrants. 1. Mortality from cancer and other diseases among Japanese in the United States.J Natl Cancer Inst 40, 43 (1968).

    PubMed  CAS  Google Scholar 

  3. Haenszel W, Kurihara M, Segi M: Stomach cancer among Japanese in Hawaii.J Natl Cancer Inst 49, 969 (1972).

    PubMed  CAS  Google Scholar 

  4. Imai T, Kubo T, Watanabe, H: Chronic gastritis in Japanese with reference to high incidence of gastric carcinoma.J Natl Cancer Inst 47, 179 (1971).

    PubMed  CAS  Google Scholar 

  5. Correa P, Cuello C, Duque E: Carcinoma and intestinal metaplasia of the stomach in Colombian migrants.J Natl Cancer Inst 44, 297 (1970).

    PubMed  CAS  Google Scholar 

  6. Haenszel W, Correa P, Cuello C, Guzman N, Burbano L C, Lores H, Munoz J: Gastric cancer in Colombia. II. Case-control epidemiologic study of precursor lesions.J Natl Cancer Inst 57, 1021 (1976).

    PubMed  CAS  Google Scholar 

  7. Sugimura T, Kawachi T, Kogure K, Tanaka N, Kazama S, Koyama Y: A novel method for detecting intestinal metaplasia of the stomach with Tes-tape.Gann 62, 237 (1971).

    PubMed  CAS  Google Scholar 

  8. Sugimura T, Kawachi T, Kogure K, Tokunaga A, Tanaka N, Sasajima K, Koyama Y, Hirota T, Sano R: Enzymological changes in abnormal differentiation: Intestinal metaplasia in human gastric mucosa: A possible precancerous change, in Nakahara W, Ono T, Sugimura T, Sugano H (eds):Differentiation and Control of Malignancy of Tumor Cells, pp. 251–261. Tokyo, University of Tokyo Press (1974).

    Google Scholar 

  9. Nakahara K, Tomoda H, Furusawa M, Abe M, Horie A: Macroscopic demonstration of the distribution of intestinal metaplasia by leucine aminopeptidase activity.Gann 67, 917 (1976).

    PubMed  CAS  Google Scholar 

  10. Fujiki H, Sugimura T: New classes of tumor promoters: teleocidin, aplysiatoxin and palytoxin.Ad Cancer Res 49, 223 (1987).

    Article  CAS  Google Scholar 

  11. Bialojan C, Takai A: Inhibitory effect of a marinesponge toxin, okadaic acid, on protein phosphatases, specificity and kinetics.Biochem J 256, 283 (1988).

    PubMed  CAS  Google Scholar 

  12. Haystead T A J, Sim A T R, Carling D, Honnor R C, Tsukitani Y, Cohen P, Hardie D G: Effects of the tumor promoter okadaic acid on intracellular protein phosphorylation and metabolism.Nature 337, 78 (1989).

    Article  PubMed  CAS  Google Scholar 

  13. Nakahara W, Fukuoka F, Sugimura T: Carcinogenic action of 4-nitroquinoline-N-oxide.Gann 48, 129 (1957).

    CAS  Google Scholar 

  14. Ito N:In vivo carcinogenesis of 4-nitroquinoIine 1- oxide and related compounds, in Sugimura T (ed):The Nitroquinolines, Carcinogenesis - A Comprehensive Survey, vol. 6, pp. 117–153. New York, Raven Press (1981).

    Google Scholar 

  15. Schoental R: Carcinogenic activity of N-methyl-N- nitroso-N’-nitroguanidine.Nature 209, 726 (1966).

    Article  PubMed  CAS  Google Scholar 

  16. Sugimura T, Nagao, M, Okada Y: Carcinogenic action of N-methyl-N’-nitro-N-nitrosoguanidine.Nature 210, 962 (1966).

    Article  PubMed  CAS  Google Scholar 

  17. Sugimura T, Fujimura S: Tumor production in glandular stomach of rat by N-methyl-N’-nitro-N-nitroso- guanidine.Nature 216, 943 (1967).

    Article  PubMed  CAS  Google Scholar 

  18. Ohgaki H, Sugimura T: Experimental stomach cancer, in Douglass H O Jr (ed):Contemporary Issues in Clinical Oncologv, vol. 8,Gastric Cancer, pp. 27–54. New York, Churchill Livingstone (1988).

    Google Scholar 

  19. Matsukura N, Kawachi T, Sasajima K, Sano T, Sugimura T, Hirota, T: Induction of intestinal metaplasia in the stomachs of rats by N-methyl-N-nitro-N- nitrosoguanidine.J Natl Cancer Inst 61, 141 (1978).

    PubMed  CAS  Google Scholar 

  20. Sugimura T: Studies on environmental chemical carcinogenesis in Japan.Science 233, 312 (1986).

    Article  PubMed  CAS  Google Scholar 

  21. Ohgaki H, Hasegawa H, Suenaga M, Kato T, Sato S, Takayama S, Sugimura T: Induction of hepatocellular carcinoma and highly metastatic squamous cell carcinomas in the forestomach of mice by feeding 2-amino- 3,4-dimethylimidazo[4,5-f]quinoline.Carcinogenesis 7, 1889 (1986).

    Article  PubMed  CAS  Google Scholar 

  22. Yamashita K, Wakabayashi K, Kitagawa Y, Nagao M, Sugimura T:32P-Postlabeling analysis of DNA adducts in rat stomach with l-nitrosoindole-3-aceto-nitrile, a direct-acting mutagenic indole compound formed by nitrosation.Carcinogenesis 9, 1905 (1988).

    Article  PubMed  CAS  Google Scholar 

  23. Hirayama T: The epidemiology of cancer of the stomach in Japan; with special reference to the role of diet.Gann Monogr 3, 15 (1968).

    Google Scholar 

  24. Hirayama T: Epidemiology of stomach cancer.Gann Monogr 11, 3 (1971).

    Google Scholar 

  25. Tatematsu M, Takahashi M, Fukushima S, Hananouchi M, Shirai T: Effects in rats of sodium chloride on experimental gastric cancers induced by N-methyl-N’-nitro-N-nitrosoguanidine or 4-nitroquinoline-l-oxide.J Natl Cancer Inst 55, 101 (1975).

    PubMed  CAS  Google Scholar 

  26. Shirai T, Imaida K, Fukushima S, Hasegawa R, Tatematsu M, Ito N: Effects of NaCl, Tween 60 and a low dose of N-ethyl-N’-nitro-N-nitrosoguanidine on gastric carcinogenesis of rat given a single dose of N-methyl-N’-nitro-N-nitrosoguanidine.Carcinogenesis 3, 1419 (1982).

    Article  PubMed  CAS  Google Scholar 

  27. Takahashi M, Kokubo T, Furukawa F, Kurokawa Y, Tatematsu M, Hayashi Y: Effect of high salt diet on rat gastric carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine.Gann 74, 28 (1983).

    PubMed  CAS  Google Scholar 

  28. Takahashi M, Kokubo T, Furukawa F, Kurokawa Y, Hayashi Y: Effects of sodium chloride, saccharin, phenobarbital and aspirin on gastric carcinogenesis in rats after initiation with N-methyl-N’-nitro-N-nitroso-guanidine.Gann 75, 494 (1984).

    PubMed  CAS  Google Scholar 

  29. Ohgaki H, Kato T, Morino K, Matsukura N, Sato S, Takayama S, Sugimura T: Study of the promoting effect of sodium chloride on gastric carcinogenesis by N-methyl-N’-nitro-N-nitrosoguanidine in inbred Wistar rats.Gann 75, 1053 (1984).

    PubMed  CAS  Google Scholar 

  30. Takahashi M, Okayama H, Furukawa F, Sato H, Hasegawa R, Shimoji N, Jang J J, Hayashi Y: Promoting effect of lower dose sodium chloride on rat gastric carcinogenesis, in Proceedings of the Japanese Cancer Association, 47th Annual Meeting (Tokyo), p. 83 (September 1988).

  31. Hirose M, Kurata Y, Tsuda H, Fukushima S, Ito N: Catechol strongly enhances rat stomach carcinogenesis: a possible new environmental stomach carcinogen.Jap J Cancer Res (Gann) 78, 1144 (1987).

    CAS  Google Scholar 

  32. Raff R, Ettling B V: Hydroquinone, resorcinol and pyrocatechol.Encycl Chem Technol 2nd Ed 11, 462 (1966).

    CAS  Google Scholar 

  33. Rahn W, König W A: GC/MS investigations of the constituents in a dietary ether extract of an acidified roast coffee infusion.J High-Resolut Chromatogr 1, 69 (1979).

    Article  Google Scholar 

  34. Hirose M, Yamaguchi S, Fukushima S, Hasegawa R, Takahashi S, Ito N: Promotion by dihydroxybenzene derivatives of N-methyl-N’-nitro-N-nitrosoguanidine-induced F344 rat forestomach and glandular stomach carcinogenesis.Cancer Res 49, 5143 (1989).

    PubMed  CAS  Google Scholar 

  35. Furihata C, Hatt A, Matsushima T: Inductions of ornithine decarboxylase and replicative DNA synthesis but not DNA single strand scission or unscheduled DNA synthesis in the pyloric mucosa of rat stomach by catechol.Jpn J Cancer Res 80, 1052 (1989).

    PubMed  CAS  Google Scholar 

  36. Okamiya H, Takahashi M, Hasegawa T, Furukawa F, Shinoda K, Imaida K, Hayashi Y: Effects of sodium chloride on lipid peroxidation and cell proliferation in rat gastric mucosa, in Proceedings of the Japanese Cancer Association, 48th Annual Meeting (Nagoya), p. 75 (October 1989).

  37. Furihata C, Sudo K, Matsushima T: Calcium chloride inhibits stimulation of replicative DNA synthesis by sodium chloride in the pyloric mucosa of rat stomach.Carcinogenesis 10, 2135 (1989).

    Article  PubMed  CAS  Google Scholar 

  38. Fine D H, Challis B C, Hartman P, Van Ryzin J: Endogenous synthesis of volatile nitrosamines: Model calculations and risk assessment, in Bartsch H, O’Neill I K, Castegnaro M, Okada M, Davis W (eds):N-Nitroso Compounds: Occurrence and Biological Effects, IARC Scientific Publications No. 41, pp. 379- 396, Lyon, IARC (1982).

    Google Scholar 

  39. Vogelstein B, Fearon E R, Hamilton S R. Kern S E, Preisinger A C, Leppert M, Nakamura Y, White R, Smits A M M, Bos J L: Genetic alterations during colorectal-tumor development.N Engl J Med 319, 525 (1988).

    PubMed  CAS  Google Scholar 

  40. Yokota J, Wada M, Shimosato Y, Terada M, Sugimura T: Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung.Proc Nad Acad Sci (USA)84, 9252 (1987).

    Article  CAS  Google Scholar 

  41. Kihana T, Tsuda H, Hirohashi S, Hirota T, Shimosato Y, Terada M: Point mutation of c-Ki-ras proto-oncogene in gastric adenocarcinoma and adenoma, inProceedings of Japanese Cancer Association, 48th Annual Meeting (Nagoya) p. 123 (October 1988).

  42. Jiang W, Kahn S M, Guillem J G, Lu S-H, Weinstein I B: Rapid detection ofras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer.Oncogene 4, 923 (1989).

    PubMed  CAS  Google Scholar 

  43. Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M: Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.Cell 53, 549 (1988).

    Article  PubMed  CAS  Google Scholar 

  44. Bos J L, Fearon E R, Hamilton S R, Veriaan-de Vries M, van Boom J H, van der Eb A J, Vogelstein B: Prevalence ofras gene mutations in human colorectal cancers.Nature 327, 293 (1987).

    Article  PubMed  CAS  Google Scholar 

  45. Forrester K, Almoguera C, Han K, Grizzle W E, Perucho M: Detection of high incidence of K-ras oncogenes during human colon tumorigenesis.Nature 327, 298 (1987).

    Article  PubMed  CAS  Google Scholar 

  46. Yokota J, Yamamoto T, Miyajima N, Toyoshima K, Nomura N, Sakamoto H, Yoshida T, Terada M, Sugimura T: Genetic alterations of the c-erbB-2 oncogene occur frequently in tulpular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue.Oncogene 2, 283 (1988).

    PubMed  CAS  Google Scholar 

  47. Nakatani H, Tahara E, Yoshida T, Sakamoto H, Terada M, Sugimura T: Amplified DNA fragments associated with gastric cancers, inProceedings of Japanese Cancer Association, 46th Annual Meeting (Tokyo) p. 118 (September 1987).

  48. Nakasato F, Sakamoto H, Mori M, Hayashi K, Shimosato Y, Nishi M, Takao S, Nakatani K, Terada M, Sugimura T: Amplification of the c-myc oncogene in human stomach cancers.Gann 75, 737 (1984).

    PubMed  CAS  Google Scholar 

  49. Seki T, Fujii G, Mori S, Tamaoki N, Shibuya M: Amplification of c-yes-1 proto-oncogene in a primary human gastric cancer.Jpn J Cancer Res (Gann)76, 907 (1985).

    PubMed  CAS  Google Scholar 

  50. Bos J L, Verlaan-de Vries M, Marshall C J, Veene-man G H, van Boom J H, van der Eb, A J: A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-ras oncogene.Nucleic Acids Res 14, 1209 (1986).

    Article  PubMed  CAS  Google Scholar 

  51. Staal S P: Molecular cloning of theakt oncogene and its human homologuesAKT1 and AKT2: amplification ofAKT1 in a primary human gastric adenocarcinoma.Proc Nad Acad Sci (USA)84, 5034 (1987).

    Article  CAS  Google Scholar 

  52. Nomura N, Yamamoto T, Toyoshima K, Ohami H, Akimaru K, Sasaki S, Nakagami Y, Kanauchi H, Shoji T, Hiraoka Y, Matsui M, Ishizaki R: DNA amplification of the c-myc and c-erbB-1 genes in a human stomach cancer.Jpn J Cancer Res (Gann)77, 1188 (1986).

    PubMed  CAS  Google Scholar 

  53. Yoshida M C, Wada M, Satoh H, Yoshida T, Sakamoto H, Miyagawa K, Yokota J, Koda T, Kakinuma M, Sugimura T, Terada M: HumanHST1 (HSTF1) gene maps to chromosome band 11ql3 and coamplifies with theINT2 gene in human cancer.Proc Nad Acad Sci (USA)85, 4861 (1988).

    Article  CAS  Google Scholar 

  54. Wada M, Yokota J, Mizoguchi H, Sugimura T, Terada M: Infrequent loss of chromosomal heterozygosity in human stomach cancer.Cancer Res 48, 2988 (1988).

    PubMed  CAS  Google Scholar 

  55. Motomura K, Nishisho I, Takai S, Tateishi H, Okazaki M, Yamamoto M, Miki T, Honjo T, Mori T: Loss of alleles at loci on chromosome 13 in human primary gastric cancers.Genomics 2, 180 (1988).

    Article  PubMed  CAS  Google Scholar 

  56. Wada M, Yokota J, Mizoguchi H, Terada M, Sugimura T: Y chromosome abnormality in human stomach and lung cancer.Jpn J Cancer Res (Gann)78, 780 (1987).

    PubMed  CAS  Google Scholar 

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  1. National Cancer Center, 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104, Japan

    Takashi Sugimura & Keiji Wakabayashi

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  1. Takashi Sugimura
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  2. Keiji Wakabayashi
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Sugimura, T., Wakabayashi, K. Gastric carcinogenesis: Diet as a causative factor. Med. Oncol. & Tumor Pharmacother. 7, 87–92 (1990). https://doi.org/10.1007/BF02988535

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