Skip to main content
Log in

Low Frequency ofBCL10 Gene Mutations in B-Cell Non-Hodgkin’s Lymphoma

  • Case Report
  • Published:
International Journal of Hematology Aims and scope Submit manuscript

Abstract

TheBCL10 gene was identified at the breakpoint region of the t(1;14)(p22;q32) translocation in mucosa-associated lymphoid tissue lymphoma. Initially, mutations in theBCL10 gene were reported to occur at a high frequency in various types of lymphomas and solid tumors. However, subsequent studies showed that the mutations were rarely recognized.To evaluate the frequency and spectrum of its mutations in B-cell non-Hodgkin’s lymphoma (B-NHL), we screened 56 cases with B-NHL by mutation analysis of exons 2 and 3 of the gene. In addition to 2 polymorphisms, a frame-shift mutation and a missense mutation were identified in 2 cases (3.6%): 1 with diffuse large B-cell lymphoma and the other with mantle cell lymphoma. Both cases showed mutations within exon 3, resulting in a C-terminal truncation in the former and a C-terminal amino acid substitution in the latter. Reverse transcriptase-polymerase chain reaction analysis of the former case revealed that both the mutated and the wild-type alleles were transcribed with or without a sequence modification. Our results, together with recent reports, indicate thatBCL10 gene mutations take place in a small population of B-NHL and are not associated with specific histological subtypes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Willis TG, Jadayel DM, Du MQ, et al.BCL10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.Cell. 1999;96:35–45.

    Article  PubMed  CAS  Google Scholar 

  2. Zhang Q, Siebert R, Yan M, et al. Inactivating mutations and over-expression o.BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).Nat Genet. 1999;22:63–68.

    Article  PubMed  CAS  Google Scholar 

  3. Koseki T, Inohara N, Chen S, et al. CIPER, a novel NF κB-activating protein containing a caspase recruitment domain with homology t. herpesvirus-2 protein E10.J Biol Chem. 1999;274:9955–9961.

    Article  PubMed  CAS  Google Scholar 

  4. Thome M, Maritinon F, Hofmann K, et al. Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-κB transcription factor and c-Jun N-terminal kinase.J Biol Chem. 1999;274:9962–9968.

    Article  PubMed  CAS  Google Scholar 

  5. Yan M, Lee J, Schilbach S, Goddard A, Dixit V. mE10, a novel caspase recruitment domain-containing proapoptotic molecule.J Biol Chem. 1999;274:10287–10292.

    Article  PubMed  CAS  Google Scholar 

  6. Fakruddin JM, Chaganti RSK, Murty VVVS. Lack o.BCL10 mutations in germ cell tumors and B cell lymphomas.Cell. 1999;97:683–684.

    Article  PubMed  CAS  Google Scholar 

  7. Apostolou S, Rienzo AD, Murthy SS, Jhanwar SC, Testa JR. Absence o.BCL10 mutations in human malignant mesothelioma.Cell. 1999;97:684–686.

    Article  PubMed  CAS  Google Scholar 

  8. Gill S, Broni J, Jefferies S, et al.BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas.Br J Cancer. 1999;80:1565–1568.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Stone JG, Rowan AJ, Tomlison IPM, Houlston RS. Mutations i.BCL10 are very rare in colorectal cancer.Br J Cancer. 1999;80:1569–1570.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. van Schothorst EM, Mohkamsing S, van Gurp RJHLM, Oosterhuis JW, van der Saag PT, Looijenga LHJ. Lack o.BCL10 mutations in testicular germ cell tumours and derived cell lines.Br J Cancer. 1999;80:1571–1574.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Lambers AR, Gumbs C, Ali S, et al.BCL10 is not a target for frequent mutation in human carcinomas.Br J Cancer. 1999;80:1575–1576.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Takahashi H, Hosokawa Y, Suzuki R, Morishima Y, Nakamura S, Seto M. Infrequen.BCL10 mutations in B-cell non-Hodgkin’s lymphomas.Jpn J Cancer Res. 1999;90:1316–1320.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Luminari S, Intini D, Baldini L, et al.BCL10 gene mutations rarely occur in lymphoid malignancies.Leukemia. 2000;14:905–908.

    Article  PubMed  CAS  Google Scholar 

  14. Du MQ, Peng H, Liu H, et al.BCL10 gene mutation in lymphoma.Blood. 2000;95:3885–3890.

    PubMed  CAS  Google Scholar 

  15. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group.Blood. 1994;84:1361–1392.

    CAS  PubMed  Google Scholar 

  16. Grimwade D, Du MQ, Langabeer S, et al. Screening for mutations o.BCL10 in leukemia.Br J Cancer. 2000;109:611–615.

    CAS  Google Scholar 

  17. Takahashi H, Maeda Y, Seto M, Hosokawa Y. Nucleotide insertions and deletions within the homopolymeric runs of adenines and thymidines o.BCL10 cDNA in normal peripheral blood leukocytes.Blood. 2000;15:2728–2729.

    Google Scholar 

  18. Dyer MJS, Price HP, Jadayel DM, et al. In response to Fakruddin et al and Apostolou et al.Cell. 1999;97:686–688.

    Article  CAS  Google Scholar 

  19. Dyer MJ.BCL10 mutations in malignancy.Br J Cancer. 1999;80:1491.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kinuko Mitani.

About this article

Cite this article

Tadokoro, J., Nakamura, Y., Furusawa, S. et al. Low Frequency ofBCL10 Gene Mutations in B-Cell Non-Hodgkin’s Lymphoma. Int J Hematol 73, 222–225 (2001). https://doi.org/10.1007/BF02981941

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02981941

Key words

Navigation