Abstract
The bioactivity-guided fractionation of the methylene chloride extract of the sclerotium ofPoria cocos led to the isolation of (S)-(+)-turmerone (1), ergosterol peroxide (2), polyporenic acid C (3), dehydropachymic acid (4), pachymic acid (5), and tumulosic acid (6). Compounds4-6 exhibited moderate cytotoxicities, with IC50 values of 20.5, 29.1, and 10.4 αM, respectively, against a human colon carcinoma cell line. However,3-6 not only showed inhibitory activities as potent as etoposide used as a positive control on DNA topoisomerase II (36.1, 36.2, 43.9 and 66.7% inhibition at a concentration of 20 μM, respectively), but also inhibition of DNA topoisomerase I (55.8, 60.7, 43.5, and 83.3% inhibition at a concentration of 100 μM, respectively).
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Li, G., Xu, ML., Lee, CS. et al. Cytotoxicity and dna topoisomerases inhibitory activity of constituents from the sclerotium ofPoria cocos . Arch Pharm Res 27, 829–833 (2004). https://doi.org/10.1007/BF02980174
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DOI: https://doi.org/10.1007/BF02980174