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Norisoprenoids and hepatoprotective flavone glycosides from the aerial parts ofBeta vulgaris var.cicla

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Abstract

(+)-Dehydrovomifoliol (1), 3-hydroxy-5α,6α-epoxy-β-ionone (2), vitexin 7-O-β-D-glucopyrano-side (3), and vitexin 2″-O-β-D-glucopyranoside (4) were isolated as new constituents from the aerial parts ofBeta vulgaris var.cicla. Compounds3 and4 demonstrated hepatoprotective activity with values of 65.8 and 56.1%, respectively, in primary cultured rat hepatocytes with CCI4-induced cell toxicity, compared to controls. This was comparable to that of silibinin (69.8 %) which was used as a positive control.

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References

  • Achenbach, H., Lottes, M., Waibel, R., Karikas, G. A., Correa, M. D., and Gupta, M. P., Alkaloids and other compounds fromPsychotria correae.Phytochemistry, 38, 1537–1545 (1995).

    Article  CAS  Google Scholar 

  • Agrawal, P. K. and Bansal, M. C., Flavonoid glycosides: In Agrawal P. K. (Eds). Carbon-13 NMR of Ravonoids. Elsevier, Amsterdam, pp. 283–364, (1989).

    Google Scholar 

  • Banskota, A. H., Tezuka, Y., Adnyana, I. K., Xiong, Q., Hase, K., Tran, K. Q., Tanaka, K., Saiki, I., and Kadota, S., Hepatoprotective effect ofCombretum quadrangulare and its constituents.Biol. Pharm. Bull., 23, 456–460 (2000).

    PubMed  CAS  Google Scholar 

  • Chin, Y.-W., Lim, S. W., Kim, S.-H., Sin, D.-Y, Sur, Y.-G., Kim, Y. B., Kim, Y. C., and Kim, J., Hepatoprotective pyrrole derivatives ofLycium chinense fruits.Bioorg. Med. Chem. Lett., 13, 79–81 (2003).

    Article  PubMed  CAS  Google Scholar 

  • Chopin, J., Dellamonica, G., Markham, K. R., Ramachandran Nair, A. G., and Gunasegaran, R., 2″-p-Coumaroylvitexin 7-glucoside fromMollugo oppositifolia.Phytochemistry, 23, 2106–2108 (1984).

    Article  CAS  Google Scholar 

  • Ito, H., Kobayashi, E., Li, S.-H., Hatano, T., Sugita, D., Kubo, N., Shimura, S., Itoh, Y., and Yoshida, T., Megastigmane gycosides and an acylated triteterpenoid fromEriobotrya japonica.J. Nat. Prod., 64, 737–747 (2001).

    Article  PubMed  CAS  Google Scholar 

  • Gil, M. I., Ferreres, F., and Tomas-Barberan, F. A., Effect of modified atmosphere packaging on the flavonoids and vitamin C content of minimally processed Swiss chard (Befa vulgaris subspecies cycla).J. Agri. Food. Chem., 46, 2007–2012 (1998).

    Article  CAS  Google Scholar 

  • Kato, T., Tsunakawa, M., Sasaki, N., and Aizawa, H., Growth and germination inhibitors in rice husks.Phytochemistry, 16, 45–48 (1977).

    Article  CAS  Google Scholar 

  • Kim, Y., Han, M. S., Lee, J. S., Kim, J., and Kim, Y. C., Inhibitory phenolic amides on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells from Befavulgaris var.cicla seeds.Phytother. Res., 17, 983–985 (2003).

    Article  PubMed  CAS  Google Scholar 

  • Kisiel, W., Michalska, K., and Szneler, E., Norisoprenoids from aerial parts ofCichorium pumilum.Biochem. Syst. Ecol., 32, 343–346 (2004).

    Article  CAS  Google Scholar 

  • Markham, K. R. and Geiger, H., “The Flavonoids,” ed. by Harbone J.B., Chapman and Hall, London, 1993, pp. 441–497.

    Google Scholar 

  • Miyase, T., Ueno, A., Takizawa, N., Kobayashi, H., and Karasawa, H., Studies on the glycosides ofEpimedium grandiflorum Morr. var.thunbergianum (Miq.) Nakai.Chem. Pharm. Bull., 35, 1109–1117 (1987).

    CAS  Google Scholar 

  • Reitman, S. and Frankel, S. A., A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.Am. J. Clin. Pathol., 28, 56–63 (1957).

    PubMed  CAS  Google Scholar 

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Correspondence to Jinwoong Kim.

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Kim, I., Chin, YW., Lim, S.W. et al. Norisoprenoids and hepatoprotective flavone glycosides from the aerial parts ofBeta vulgaris var.cicla . Arch Pharm Res 27, 600–603 (2004). https://doi.org/10.1007/BF02980156

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