Abstract
Possible antiinflammatory effects of eudesmin were examined by assessing the effects on tumor necrosis factor (TNF)-α production and lymphocyte proliferation as well as cytotoxicity against murine and human macrophages. The compound significantly inhibited TNF-α production by lipopolysaccharide (LPS)-stimulated murine macrophage RAW264.7 without displaying cytotoxicity suggesting that eudesmin may inhibit TNF-α production without any interference of normal cell function. It also significantly attenuated T cell proliferation stimulated by concanavalin A (Con A) in a dose-dependent manner.
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Cho, J.Y., Yoo, E.S., Baik, K.U. et al. Eudesmin inhibits tumor necrosis factor-α production and T cell proliferation. Arch Pharm Res 22, 348–353 (1999). https://doi.org/10.1007/BF02979056
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DOI: https://doi.org/10.1007/BF02979056