Abstract
Nine diarylheptanoids (1–9), one triterpene (10), one sesquiterpenoid (11), one naphthoquinone (12), four tetralones (13–16), one naphthalene carboxylic acid glucoside (17) and six naphthalenyl glycosides (18–23) were isolated from the roots ofJuglans mandshurica Maxi-mowicz (Juglandaceae), and their structures determined from the chemical and spectral data. Here, we report the inhibitory effects, on the DNA topoisomerases I and II activities, of all these compounds. Compounds10 and23 showed more potent inhibitory effects, on the DNA topoisomerases I and II (94.0 and 86.0% inhibitions at the concentration of 5 (μg/mL, respectively), than the positive control compounds, camptothecin and etoposide.
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References
Chen, A. Y. and Liu, L. F., DNA topoisomerases: essential enzymes and lethal targets.Annu. Rev. Pharmacol. Toxicol., 34, 191–218 (1994).
DArpa, P. and Liu, L. F., Topoisomerase-targeting antitumor drugs.Biochim. Biophys. Acta., 989, 163–177 (1989).
Fukuda, M., Nishio, K., Kanzawa, F., Ogasawara, H., Ishida, T., Arioka, H., Bojamowski, K., Oka, M., and Saijo, N., Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38, in human small cell lung cancer cells.Cancer Res., 56, 789–793 (1996).
Joe, Y. K., Son, J. K., Park, S. H., Lee, I. J., and Moon, D. C., Isolation and structure determination of a new tetralone glucoside from the roots ofJuglans mandshurica.J. Nat. Prod., 59, 159–160 (1996).
Kim, S. H., Lee, K. S., Son, J. K., Je, G. H., Lee, J. S., Lee, C.H., and Cheong, C. J., Cytotoxic compounds from the roots ofJuglans mandshurica.J. Nat. Prod., 61, 643–645 (1998).
Lee, K. S., Li, G., Kim, S. H., Lee, C. S., Woo, M. H., Lee, S. H., Jahng, Y. D., and Son, J. K., Cytotoxic Diarylheptanoids from the roots ofJuglans mandshurica.J. Nat. Prod., 65, 1707–1708 (2002).
Lee, S. W., Lee, K. S., and Son, J. K., New naphthalenyl glycosides from the roots ofJuglans mandshurica.Planta Med., 66, 184–186 (2000).
Li, G., Xu, M. L., Choi, H. G., Lee, S. H., Jahng, Y. D., Lee, C.S., Moon, D. C., Woo, M. H., and Son, J. K., Four diarylheptanoids from the roots ofJuglans mandshurica.Chem. Pharm. Bull., 51, 262–264 (2003)
Liu, L. F., DNA topoisomerase poisons as antitumor drugs.Annu. Rev. Biochem., 58, 351–375 (1989).
Pommier, Y., DNA topoisomerase I and II in cancer chemotherapy: update and perspectives.Cancer Chemother. Pharmacol., 32, 103–108 (1993).
Potmesil, M., Camptothecins: from bench research to hospital wards.Cancer Res., 54, 1431–1439 (1994).
Rubinstein, L. V., Shoemaker, R. H., Paul, K. D., Simon, R. M., Tosini, S., Skehan, P., Scudiero, D. A., Monks, A., and Boyd, M. R., Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines.J. Nat. Cancer Inst., 82, 1113–1118 (1990).
Shaari, K. and Waterman, P. G., Constituents o.Scaphocalyx spatacea (Flacourtiaceae),Malaysian J. Science, 17B, 37–40 (1996).
Slichenmyer, W. J., Rowinsky, E. K., Donehower, R. C., and Kaufmann, S. H., The current status of camptothecin analogues as antitumor agents.J. Natl. Cancer Inst., 85, 271–291 (1993).
Son, J. K., Isolation and structure determination of a new tetralone glucoside from the roots ofJuglans mandshurica.Arch. Pharm. Res., 18, 203–205 (1995).
Wang, J. C., DNA topoisomerases.Annu. Rev. Biochem., 65, 635–692 (1996).
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Li, G., Lee, S.Y., Lee, K.S. et al. DNA topoisomerases I and II inhibitory activity of constituents isolated fromJuglans mandshurica . Arch Pharm Res 26, 466–470 (2003). https://doi.org/10.1007/BF02976864
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DOI: https://doi.org/10.1007/BF02976864