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Synthesis and anti-inflammatory activity of fructigenine a derivatives

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Abstract

Several derivatives were synthesized from fructigenine A, which was isolated fromPenicillium fructigenum. The anti-inflammatory properties of fructigenine A was evaluatedin vivo with a 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema model and a carrageenan-induced rat paw edema model. Results showed that the anti-in flammatory activity was significantly higher with fructigenine derivatives than with indomethacin, which was used as a standard. We concluded that fructigenine derivatives could exert an anti-inflammatory effect.

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Authors and Affiliations

  1. CJ Corporation, 522-1 Dokpyong-Ri, Majang-Myun, Ichon-Si, 467-810, Kyonggi-Do, Korea

    Jun-Hwan Chang

  2. SK R&D Center, 140-1 Wonchon-Dong, Yuseong-Gu, 305-712, Daejeon, Korea

    Hong-sik Moon

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  1. Jun-Hwan Chang
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  2. Hong-sik Moon
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Correspondence to Hong-sik Moon.

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Chang, JH., Moon, Hs. Synthesis and anti-inflammatory activity of fructigenine a derivatives. Biotechnol Bioproc E 9, 59–61 (2004). https://doi.org/10.1007/BF02949323

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  • DOI: https://doi.org/10.1007/BF02949323

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