Abstract
Sera of 426 adult persons were examined to assess the prevalence of SEN virus (SENV) infection in Slovakia and to determine the importance of different risk factors for parenteral transmission. SENV prevalence was determined by the PCR method using primers of SENV-D and SENV-H strains. Positive results were found in 10 of 37 patients with acute hepatitis of unknown etiology, 7 of 38 with acute hepatitis B, 17 of 44 with chronic hepatitis B, 29 of 102 with chronic hepatitis C, 36 of 72 hemodialysis patients, 2 of 33 health care workers and 24 of 100 persons from the control group. The highest prevalence of SENV was among hemodialysis patients, significantly higher than in the groups of health care workers, acute hepatitis B and controls. The lowest prevalence was in health care workers group, significantly lower also in comparison with groups of chronic hepatitis B and C. Among the possible risk factors of virus transmission the average duration of hemodialysis (1.15vs. 0.50 years), number of surgeries (1.60vs. 1.10) and transfusions (1.34vs. 0.94) showed notable differences in terms of SENV infection. Bilirubin and aminotransferase levels did not differ between SENV-positive and -negative groups. No pathogenetic role of SEN virus in liver injury was confirmed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alter H.J., Bradley D.W.: Non-A, non-B hepatitis unrelated to the hepatitis C virus (non-ABC).Semin.Liver Dis. 15, 110–120 (1995).
Alter M.J., Margolis H.S., Krawczynski K., Judson F.N., Mares A., Alexander W.J., Hu P.Y., Miller J.K., Gerber M.A., Sampliner R.E., Meeks E.L., Beach M.J.: The natural history of community-acquired hepatitis C in the United States.N.Engl.J.Med. 327, 1899–1905 (1992).
Blaha M., Méřička P., Stèpanova V., Maly J., Vavra L., Jebavy L.: Potential risk of infection transmission during storage and transplantation of hematological progenitor cells. Safety assurance.Folia Microbiol. 48, 399–402 (2003).
Kao J.H., Chen W., Chen P.J., Lai M.Y., Chen D.S.: Prevalence and implication of a newly identified infectious agent (SEN virus) in Taiwan.J.Infect.Dis. 185, 389–392 (2002).
Kobayashi N., Tanaka E., Umemura T., Matsumoto A., Iijima T., Higuchi M., Hora K., Kiyosawa K.: Clinical significance of SEN virus infection in patients on maintenance hemodialysis.Nephrol.Dial.Transplant. 18, 348–352 (2003).
Kojima H., Kaita K.D., Zhang M., Giulivi A., Minuk G.Y.: Genomic analysis of a recently identified virus (SEN virus) and genotypes D and H by polymerase chain reaction.Antiviral Res. 60, 27–33 (2003).
Majtán T., Bukovská G., Timko J.: DNA microarrays — techniques and applications in microbial systems.Folia Microbiol. 49, 635–664 (2004).
Mikuni M., Moriyama M., Tanaka N., Abe K., Arakawa Y.: SEN virus infection does not affect the progression of non-A to -E liver disease.J.Med.Virol. 67, 624–629 (2002).
Mu S.J., Du J., Zhan L.S., Wang H.P., Chen R., Wang Q.L., Zhao W.M.: Prevalence of a newly identified SEN virus in China.World J.Gastroenterol. 10, 2402–2405 (2004).
Nishizawa T., Okamoto H., Konishi K., Yoshizawa H., Miyakawa Y., Mayumi M.: A novel DNA virus (TTV) associated with elevated transaminase levels in post-transfusion hepatitis of unknown etiology.Biochem.Biophys.Res.Commun. 241, 92–97 (1997).
Pirovano S., Bellinzoni M., Ballerini C., Cariani E., Duse M., Albertini A., Imberti L.: Transmission of SEN virus from mothers to their babies.J.Med.Virol. 66, 421–427 (2002).
Pirovano S., Gregorini G., Malacarne F., Marini M., Albertini A., Imberti L.: High prevalence of SEN virus infection in patients on maintenance hemodialysis: frequent mixed infections with different variants and evidence for nosocomial transmission of the virus.Intervirology 48, 216–222 (2005).
Primi D., Fiordalisi G., Mantero J.L., Mattioli S., Sottini A., Bonelli F. Vaglini L., Olivero P., Dal Corso A., Bonelli M.: Identification of SENV genotypes. International patent number WO0028039 (international application published under the patent co-operation treaty) 2000; http://ep.espacenet.com/.
Schréter I., Kristian P., Birošová E., Siegfried L., Jarčuška P.: The first evidence of TT virus infection in Slovakia.Biologia 59, 409–412 (2004).
Schroter M., Laufs R., Zollner B., Knodler B., Schafer P., Feucht H.H.: A novel DNA virus (SEN) among patients on maintenance hemodialysis: prevalence and clinical importance.J.Clin.Virol. 27, 69–73 (2003).
Shibata M., Wang R.Y., Yoshiba M., Shih J.W., Alter H.J., Mitamura K.: The presence of a newly identified infectious agent (SEN virus) in patients with liver diseases and in blood donors in Japan.J.Infect.Dis. 184, 400–404 (2001).
Simons J.N., Leary T.P., Dawson G.J., Pilot-Matias T.J., Muerhoff A.S., Schlauder G.G., Desai S.M., Mushahwar I.K.: Isolation of novel virus-like sequences associated with human hepatitis.Nature Med. 1, 564–569 (1995a).
Simons J.N., Pilot-Matias T.J., Leary T.P., Dawson G.J., Desai S.M., Schlauder G.G., Muerhoff A.S., Erker J.C., Buijk S.L., Chalmers M.L., Van Sant C.L., Mushahwar I.K.: Identification of two flavivirus-like genomes in the GB hepatitis agent.Proc.Nat.Acad.Sci.USA 92, 3401–3405 (1995b).
Tanaka Y., Primi D., Wang R.Y.H., Umemura T., Yeo A.E., Mizokami M., Alter H.J., Wai-Kuo Shih J.: Genomic and molecular evolutionary analysis of a newly identified infectious agent (SEN virus) and its relationship to the TT virus family.J.Infect.Dis. 183, 359–367 (2001).
Umemura T., Yeo A.E., Sottini A., Moratto D., Tanaka Y., Wang R.Y., Shih J.W., Donahue P., Primi D., Alter H.J.: SEN virus infection and its relationship to transfusion-associated hepatitis.Hepatology 33, 1303–1311 (2001a).
Umemura T., Alter H.J., Tanaka E., Yeo A.E., Shih J.W., Orii K., Matsumoto A., Yoshizawa K., Kiyosawa K.: Association between SEN virus infection and hepatitis C in Japan.J.Infect.Dis. 184, 1246–1251 (2001b).
Wilson L.E., Umemura T., Astemborski J., Ray S.C., Alter H.J., Strathdee S.A., Vlahov V., Thomas V.L.: Dynamics of SEN virus infection among injection drug users.J.Infect.Dis. 184, 1315–1319 (2001).
Yoshida E.M., Buczkowski A.K., Giulivi A., Zou S., Forrester L.A.: A cross-sectional study of SEN virus in liver transplant recipients.Liver Transplant. 7, 521–525 (2001).
Yoshida H., Kato N., Shiratori Y., Shao R., Wang Y., Shiina S., Omata M.: Weak association between SEN virus viremia and liver disease.J.Clin.Microbiol. 40, 3140–3145 (2002).
Author information
Authors and Affiliations
Corresponding author
Additional information
This work was supported by grants 1/9330/02 and 1/2268/05 of theScientific Grant Agency of the Ministry of Education of Slovak Republic and theSlovak Academy of Sciences. We are grateful to Dr. B. Smajda and Prof. M. Mikulecký for the statistics analysis.
Rights and permissions
About this article
Cite this article
Schréter, I., Kristian, P., Jarčuška, P. et al. Detection of SEN virus in the general population and different risk groups in Slovakia. Folia Microbiol 51, 223–228 (2006). https://doi.org/10.1007/BF02932126
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02932126