Abstract
Primary hepatocellular carcinoma (HCC) is one of the most common cancers occurring in human, and there is strong epidemiological evidence suggesting that persistent hepatitis B virus (HBV) infection is the most important risk factor for its development.HBx gene was found to be a transactivator recently. Its continuous expression in hepatocytes may transactivate cellular genes which can play a certain role in development of HCC. TheHBx gene fragment was used to construct a recombinant eukaryotic expression vector pCEP4 and introduced into HepG2 cells. The effect ofHBx gene on HCC cells growth and its molecular mechanism in HCC cells regulation were investigated.
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Tao, X., Shen, D., Ren, H. et al. The role of hepatitis B virus × gene in development of primary hepatocellular carcinoma. Sci. China Ser. C.-Life Sci. 43, 293–301 (2000). https://doi.org/10.1007/BF02879289
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DOI: https://doi.org/10.1007/BF02879289