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Evaluation of new metallized direct dyes for mutagenicity using the Salmonella mammalian mutagenicity assay

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Abstract

A series of new metallized direct dyes based on benzidine congeners, 2,2′-dimethyl-5,5′-dipropoxybenzidine and 5,5′-dipropoxybenzidine, were evaluated for mutagenicity in Salmonella typhimurium strains TA98 and TA100. All of the dyes examined were judged to be non-mutagenic with and without metabolic activation while toxicity was seen in some dyes at high doses. The study also suggested that the standard Salmonella mutagenicity plate-incorporated assay was an excellent method for evaluation of dyes for mutagenicity.

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Authors and Affiliations

  1. Korea Dyeing Technology Center, 703-834, Daegu, Korea

    Jin-Seok Bae & Harold S. Freeman

  2. Department of Textile Engineering, Chemistry, and Science, North Carolina State University, 27695-8301, Raleigh, NC, USA

    Harold S. Freeman

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  1. Jin-Seok Bae
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  2. Harold S. Freeman
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Correspondence to Jin-Seok Bae.

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Bae, JS., Freeman, H.S. Evaluation of new metallized direct dyes for mutagenicity using the Salmonella mammalian mutagenicity assay. Fibers Polym 6, 235–243 (2005). https://doi.org/10.1007/BF02875648

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  • DOI: https://doi.org/10.1007/BF02875648

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