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Efficacy of a herbal preparation in patients with functional dyspepsia: A meta-analysis of double-blind, randomized, clinical trials

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Abstract

A meta-analysis was performed of double-blind, randomized clinical studies that evaluated the efficacy of the herbal preparation Iberogast in patients with functional dyspepsia. All studies had the same duration and used the same dosage of active treatment and the same primary outcome measure, a dyspepsia-specific gastrointestinal symptom score. Of the 592 trial participants, 196 were treated with Iberogast and 192 with placebo or cisapride (positive control). The individual studies all showed a substantial improvement of symptoms with Iberogast but varying results regarding its statistically significant superiority to placebo. The meta-analysis of all studies, however, demonstrated a clear, highly significant overall therapeutic effect of Iberogast in the treatment of functional dyspepsia. Tolerability of the preparation was excellent.

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References

  1. Talley NJ, Silverstein MD, Agréus L, Nyrén O, Sonnenberg A, Holtmann G. AGA technical review: evaluation of dyspepsia.Gastroenterology. 1998;114:582–595.

    Article  PubMed  CAS  Google Scholar 

  2. Drossmann DA. The functional gastrointestinal disorders and the Rome II process. A multinational consensus document on functional gastrointestinal disorders.Gut. 1999;45(suppl II):1–5.

    Google Scholar 

  3. Milosavljevic T, Jovanovic I. Functional dyspepsia.Arch Gastroenterohepatol. 2000;19:40–51.

    Google Scholar 

  4. Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GN. Functional gastroduodenal disorders.Gut. 1999;45(suppl II):37–42.

    Google Scholar 

  5. Talley N. Scope of the problem of functional digestive disorders.Eur J Surg. 1998;583(suppl): 35–41.

    Google Scholar 

  6. Talley NJ. Drug treatment of functional dyspepsia.Scand J Gastroenterol. 1991;26(suppl 182): 47–60.

    Article  Google Scholar 

  7. Holtmann G, Talley NJ. Functional dyspepsia. Current treatment recommendations.Drugs. 1993;45:918–930.

    Article  PubMed  CAS  Google Scholar 

  8. Saller R, Pfister-Hotz G, Iten F, Melzer J, Reichling J. Iberogast®: a modern phytotherapeutic combination herbal drug for the treatment of functional disorders of the gastrointestinal tract (dyspepsia, irritable bowel syndrome). A systematic review.Forschr Komplement Klass Naturheilkd. 2002;9(suppl 1):1–20.

    Article  Google Scholar 

  9. Strathmann D. Bitterer Bauernsenf bei funktionellen Magen-Darm-Störungen.Z Phytother. 1983; 4:734.

    Google Scholar 

  10. Blumenthal M, ed.The Complete German Commission E Monographs. Therapeutic Guide to Herbal Medicines. Austin, Tex: American Botanical Council; 1998.

    Google Scholar 

  11. Buchert D. Wirkung einer fixen Kombination bei gesicherter Non Ulcer Dyspepsie.Z Phytother. 1994;15:24–25.

    Google Scholar 

  12. Holtmann G, Hotz J, Mayr G, Schnitker J. A double-blind, randomized, placebo-controlled trial on the effect of an herbal preparation in patients with functional dyspepsia.Gastroenterology. 1999;116:A65.

    Google Scholar 

  13. Madisch A, Melderis H, Mayr G, Sassin I, Hotz J. Commercially available herbal preparation and its modified dispensing in patients with functional dyspepsia. Results of a double-blind, placebo-controlled, randomized multicenter trial.Z Gastroenterol. 2001;39:511–517.

    Article  PubMed  CAS  Google Scholar 

  14. Rösch W, Vinson B, Sassin I. A randomized clinical trial comparing the efficacy of an herbal preparation STW 5 with the prokinetic drug cisapride in patients with dysmotility type of functional dyspepsia.Z Gastroenterol. 2002;40:401–408.

    Article  PubMed  Google Scholar 

  15. Winer BJ. Statistical Principles in Experimental Design. New York: McGraw-Hill; 1971.

    Google Scholar 

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Gundermann, KJ., Godehardt, E. & Ulbrich, M. Efficacy of a herbal preparation in patients with functional dyspepsia: A meta-analysis of double-blind, randomized, clinical trials. Adv Therapy 20, 43–49 (2003). https://doi.org/10.1007/BF02850118

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