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CD28/CTLA-4 and CD80/CD86 families

Signaling and function

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Abstract

T cell stimulation in the absence of a second, costimulatory signal can lead to anergy or the induction of cell death. CD28 is a major T cell costimulatory receptor, the coengagement of which can prevent anergy and cell death. The CD28 receptor is a member of a complex family of polypeptides that includes at least two receptors and two ligands. Cytotoxic lymphocyte-associated molecule-4 (CTLA-4, CD152) is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). This article reviews the CD28/CTLA4 and CD80/CD86 families, and outlines the functional outcomes and biochemical signaling pathways recruited after CD28 ligation.

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Authors and Affiliations

  1. Department of Pediatrie Oncology, Dana-Farber Cancer Institute, Boston, MA

    Jacqueline M. Slavik, Jill E. Hutchcroft & Barbara E. Bierer M.D.

  2. Department of Pediatrics, Harvard Medical School, Boston, MA

    Barbara E. Bierer M.D.

  3. National Heart, Lung, and Blood Institute National Institutes of Health, Bldg. 10, Room 5D49, 10 Center Drive, 20892, Bethesda, MD

    Barbara E. Bierer M.D.

  4. Department of Biochemistry, Purdue University, West Lafayette, IN

    Jill E. Hutchcroft

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Slavik, J.M., Hutchcroft, J.E. & Bierer, B.E. CD28/CTLA-4 and CD80/CD86 families. Immunol Res 19, 1–24 (1999). https://doi.org/10.1007/BF02786473

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