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Peripheral airway function in healthy young cigarette smokers

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Abstract

We evaluated the usefulness of a number of the most widely used “small airway tests” in separating a group of 60 young (20 – 35 years) healthy cigarette smokers from a matched group of 50 nonsmokers. Only the Viso\(\dot V\), CV/VC, and CC/TLC separated both male and female smokers and nonsmokers. In addition, these tests correlated with the smoking index and detected 18% – 24% abnormalities when compared with mean values for the nonsmoking control groups.

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References

  1. Anthonisen, N. R., Bass, H., Oriol, A., Place, R. E. G., Bates, D. V.: Regional lung function in patients with chronic bronchitis. Clin. Sci.35, 495 (1968)

    PubMed  CAS  Google Scholar 

  2. Anthonisen, N. R., Dawson, J., Robertson, P. C., Ross, W. R. D.: Airway closure as a function of age. Respir. Physiol.8, 58 (1969/1970)

    Article  PubMed  CAS  Google Scholar 

  3. Bouhuys, A., Schoenberg, J. B., Beck, G. J.: Discriminatory power of MEFV curves. Fed. Proc.36, 468 (1977)

    Google Scholar 

  4. Buist, A. S., Ross, B. B.: Predicted values for closing volumes using a modified single breath nitrogen test. Am. Rev. Respir. Dis.107, 744 (1973)

    PubMed  CAS  Google Scholar 

  5. Buist, A. S., Ross, B. B.: Quantitative analysis of the alveolar plateau in the diagnosis of early airway obstruction. Am. Rev. Respir. Dis.108, 1078 (1973)

    PubMed  CAS  Google Scholar 

  6. Burrows, B., Knudson, R. J., Cline, M. G., Lebowitz, M. D.: Quantitative relationships between cigarette smoking and ventilatory function. Am. Rev. Respir. Dis.115, 195 (1977)

    PubMed  CAS  Google Scholar 

  7. Burrows, B., Hasan, F. M.: Abnormalities in small airways. Dis. Mon.23, 17 (1977)

    Google Scholar 

  8. Cosio, M., Ghezzo, H., Hogg, J. C., Corbin, R., Loveland, M., Dosman, J., Macklem, P. T.: The relations between structural changes in small airways and pulmonary function tests. N. Engl. J. Med.298, 1277 (1978)

    Article  PubMed  CAS  Google Scholar 

  9. Darling, R. C., Cournand, A., Richards, D. W.: Studies on the intrapulmonary mixture of gases: III. An open circuit for measuring residual air. J. Clin. Invest.19, 609 (1948)

    Google Scholar 

  10. Dosman, J., Bode, F., Ghezzo, R. H., Martin, R., Macklem, P. T.: The relationship between symptoms and functional abnormalities in clinically healthy cigarette smokers. Am. Rev. Respir. Dis.114, 297 (1967)

    Google Scholar 

  11. Dosman, J., Bode, F., Urbanetti, J., Martin, R., Macklem, P. T.: The use of a helium-oxygen mixture during maximum expiratory flow to demonstrate obstruction in small airways in smokers. J. Clin. Invest.55, 1090 (1975)

    Article  PubMed  CAS  Google Scholar 

  12. Dosman, J., Macklem, P. T.: Disease of small airways. Adv. Intern. Med.22, 355 (1977)

    PubMed  CAS  Google Scholar 

  13. Enjeti, S., Hazelwood, B., Permutt, S., Menkes, H., Terry, P.: Pulmonary function in young smokers: Male-female differences. Am. Rev. Respir. Dis.118, 667 (1978)

    PubMed  CAS  Google Scholar 

  14. Fletcher, C., Peto, R., Tinker, C., Speizer, F. E.: The natural history of chronic bronchitis and emphysema. Oxford: Oxford University Press, 1976

    Google Scholar 

  15. Glauser, F. L., Wilson, A. F.: Pulmonary parenchymal tissue volume in normal subjects. Chest72, 207 (1977)

    Article  PubMed  CAS  Google Scholar 

  16. Goodman, R. M., Yergin, B. M., Landa, J. F., Golinvaux, M. H., Sackner, M. A.: Relationship of smoking history and pulmonary function tests to tracheal mucous velocity in nonsmokers, young smokers, exsmokers, and patients with chronic bronchitis. Am. Rev. Respir. Dis.117, 205 (1978)

    PubMed  CAS  Google Scholar 

  17. Harrison, G. N., Moor, G. R., Mohler, J. L., Speir, W. A.: Small airway disease: Comparison of tests in young smokers versus nonsmokers. South. Med. J.71, 1079 (1978)

    PubMed  CAS  Google Scholar 

  18. Hayashi, M., Sornberger, G. C., Huber, G. L.: Morphometric analyses of tracheal gland secretion and hypertrophy in male and female rats after experimental exposure to tobacco smoke. Am. Rev. Respir. Dis.119, 67 (1979)

    PubMed  CAS  Google Scholar 

  19. Higgins, I. T. T.: Epidemiology of chronic respiratory disease: A literature review. Washington, D.C.: Office of Research and Development, U.S. Environmental Protection Agency, 1974 (EPA-650/1-74-007)

    Google Scholar 

  20. Higgins, M. W., Keller, J. B., Metzner, H. L.: Smoking, socioeconomic status and chronic respiratory disease. Am. Rev. Respir. Dis.116, 403 (1977)

    PubMed  CAS  Google Scholar 

  21. Hogg, J. C., Macklem, P. T., Thurlbeck, W. M.: Site and nature of airway obstruction in chronic obstructive lung disease. N. Engl. J. Med.278, 1355 (1968)

    Article  PubMed  CAS  Google Scholar 

  22. Hutcheon, M., Griffin, P., Levison, H., Zamel, N.: Volume of isolfow. A new test in detection of mild abnormalities of lung mechanics. Am. Rev. Respir. Dis.110, 458 (1974)

    PubMed  CAS  Google Scholar 

  23. Ingram, R. R., O’Cain, C. F.: Frequency dependence of compliance in apparently healthy smokers versus non-smokers, Lung and Airways Mechanics in Normal Man and in Chronic Lung Disease. Entretiens de Physio-pathologie Respiratoire, Nancy, 8e Series (Peslin, R., ed.). Paris: Masson and Cie, 1971

    Google Scholar 

  24. Knudson, R. J., Burrows, B., Lebowitz, M. D.: The maximal expiratory flow-volume curve: Its use in the detection of ventilatory abnormalities in a population study. Am. Rev. Respir. Dis.114, 871 (1976)

    PubMed  CAS  Google Scholar 

  25. Knudson, R. J., Lebowitz, M. D.: Comparison of flow-volume and closing volume variables in a random population. Am. Rev. Respir. Dis.116, 1039 (1977)

    PubMed  CAS  Google Scholar 

  26. Knudson, R. J., Lebowitz, M. D., Burton, A. P., Knudson, D. E.: The closing volume test: Evaluation of nitrogen and bolus methods in a random population. Am. Rev. Respir. Dis.115, 423 (1977)

    PubMed  CAS  Google Scholar 

  27. Leuallen, E. C., Fowler, W. S.: Maximal midexpiratory flow. Am. Rev. Tuberc.72, 783 (1955)

    PubMed  CAS  Google Scholar 

  28. Li, J. C. R.: Statistical Inference, vol. 1, p. 143. New York: Edward Brothers, 1964

    Google Scholar 

  29. Marcq, M., Minette, A.: Lung function changes in smokers with normal conventional spirometry. Am. Rev. Respir. Dis.114, 723 (1976)

    Google Scholar 

  30. McCarthy, D. S., Spencer, R., Greene, R., Milic-Emili, J.: Measurement of “closing volume” as a simple and sensitive test for early detection of small airway disease. Am. J. Med.52, 747 (1972)

    Article  PubMed  CAS  Google Scholar 

  31. Morbidity and Mortality Weekly Report26, 160 (1977)

  32. Morbidity and Mortality Weekly Report28, 1 (1979)

  33. Morris, J. F., Koski, A., Johnson, L. C.: Spirometric standards for healthy nonsmoking adults. Am. Rev. Respir. Dis.103, 57 (1971)

    PubMed  CAS  Google Scholar 

  34. Nie, N. H., Hull, C. H., Jenkins, S. G. et al.: Statistical Package for the Social Sciences. New York: McGraw-Hill, 1975

    Google Scholar 

  35. Niewoehner, D. E., Kleinerman, J., Rice, D. B.: Pathologic changes in the peripheral airways of young cigarette smokers. N. Engl. J. Med.291, 755 (1974)

    Article  PubMed  CAS  Google Scholar 

  36. Seely, J. E., Zuskin, E., Bouhuys, A.: Cigarette smoking: Objective evidence for lung damage in teen-agers. Science172, 741 (1971)

    Article  PubMed  CAS  Google Scholar 

  37. Siegel, S.: Nonparametric Statistics, p. 47. New York: McGraw-Hill, 1956

    Google Scholar 

  38. Tager, I. B., Speizer, F. E.: Risk estimates for chronic bronchitis in smokers: A study of male-female differences. Am. Rev. Respir. Dis.113, 619 (1976)

    PubMed  CAS  Google Scholar 

  39. Tattersall, S. F., Benson, M. K., Hunter, D. et al.: The use of tests of peripheral lung function for predicting future disability from airflow obstruction in middle-aged smokers. Am. Rev. Respir. Dis.118, 1035 (1978)

    PubMed  CAS  Google Scholar 

  40. Van de Woestijne, K. P.: Specificity of tests for detection of small airway disease. Bull. Eur. Physiopathol. Resp.12, 477 (1976)

    Google Scholar 

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Authors and Affiliations

  1. Section of Pulmonary Diseases, Department of Medicine, Medical College of Georgia, Box 1085, 30912, Augusta, Georgia, USA

    G. N. Harrison, J. L. Mohler, L. A. Lewis & W. A. Speir

Authors
  1. G. N. Harrison
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  2. J. L. Mohler
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  3. L. A. Lewis
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  4. W. A. Speir
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Additional information

This study was previously presented in part to the Section on Chest Diseases, 71st Annual Scientific Assembly of the Southern Medical Association, Dallas, Texas, November 1977. It was supported in part by U. S. Public Health Service Grant 5K07HL70057, a Pulmonary Academic Award.

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Harrison, G.N., Mohler, J.L., Lewis, L.A. et al. Peripheral airway function in healthy young cigarette smokers. Lung 156, 205–215 (1979). https://doi.org/10.1007/BF02714011

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