Summary
Glycylhistidyllysine (GHL), a tripeptide isolated from plasma, has been shown to alter the growth rate of many cell types and organisms in culture systems. The tripeptide is optimally active at concentrations between 10 and 200 ng/ml. Some of the more interesting uses of GHL are highlighted in this paper. Present information suggests that GHL functions as a transporter of transition metals, in particular copper, to the cell surface for up-take into the cell.
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This work was supported by USPHS Grants CA 28858 and RR 05588.
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Pickart, L. The use of glycylhistidyllysine in culture systems. In Vitro 17, 459–466 (1981). https://doi.org/10.1007/BF02633506
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DOI: https://doi.org/10.1007/BF02633506