Summary
The authors evaluated whole blood filterability (VB) in 29 post-menopausal obese women with (n=14) or without (n=15) hypertension, and in 22 age matched women with normal body weight. After 3 months of a low-calorie (18 kcal/kg IBW) and moderately low-salt (max 6 g NaCl/day) diet, the obese subjects were restudied. In all women plasma fibrinogen values and various indices of metabolic status were evaluated before and after the diet and correlated to VB values. VB values and plasma fibrinogen concentrations were similar in normal controls and in women with simple obesity, whereas they were, respectively, significantly lower and higher in obese subjects with hypertension. Three months of diet significantly improved whole blood filterability and decreased fibrinogen levels in these patients. Before the diet a significant negative correlation was found between VB and plasma fibrinogen values in hypertensive obese patients. Metabolic parameters did not change in the different groups before and after the diet and did not correlate with VB values. The present sudy indicates that low-calorie, low-salt diet decreases plasma fibrinogen levels and improves whole blood filterability in elderly obese women with hypertension.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Boogaerts M. A., Roeland C., Temmerman J., Goessens Verwilghen R. L.: Effect of beta-blocking drugs on red cell adhesive and rheological properties — J. Lab. clin. Med.102, 899, 1983.
Brand S. C., Whittam R.: The effect of furosemide on sodium movements in human red blood cells — J. Physiol. (Lond.)348, 301, 1984.
Chiang B. N., Perlman L. V., Epstein F. H.: Overweight and hypertension — Circulation39, 403, 1969.
Dahl L. K., Silver L., Christie K. W.: The role of salt in the fall of blood pressure accompanying reduction in obesity — New Engl. J. Med.258, 1186, 1958.
Delsignore R., Gelmini G., Coiro V.: Effect of diet on whole blood filterability in obese women with impaired glucose tolerance — Med. Sci. Res.15, 1179, 1987.
Dintenfass L., Girolami A.: Rigidity of red cells in essential hypertension — Haemostasis7, 298, 1978.
Dintenfass L., Lake B.: Betablokers and blood viscosity — Lanceti, 1026, 1976.
Ernst E., Weihmayr T., Schmid M., Baumann M., Matrai A.: Cardiovascular risk factors and hemorheology: physical fitness, stress and obesity — Atherosclerosis59, 263, 1986.
Freeitas J., Braz-Nogueira J., Nogueira Da Costa J., Martins E., Silva J.: Whole blood filterability and blood oxigen transport in human hypertension — Clin. Hemorheol.3, 367, 1983.
Gelmini G., Butturini L., Cucinotta D., Delsignore R., Coiro V.: Whole blood filterability in elderly obese women — Acta diabetol. lat.24, 199, 1987.
Gelmini G., Delsignore R., Coiro V.: Evaluation of erythrocyte deformability in pre-menopausal and post-menopausal women — Maturitas9, 275, 1987.
Gelmini G., Ferretti P. G., Butturini L., Baroni M. C., Delsignore R.: Membrane postfiltration evaluation in young and elderly people by scanning electron microscopy — Giorn. Gerontol.34, 341, 1986.
Letchter R. L., Chien S., Laragh J. H.: Changes in blood viscosity accompanying the response to prazosin in patients with essential hypertension — J. Cardiovasc. Pharmacol.1, 8, 1979.
Letcher R. L., Chien S., Pickering T. G., Sealey J. E., Laragh J. H.: Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects — Amer. J. Med.70, 1195, 1981.
Longhini E., Agosti R., Cherubini P., Clivati A., Farini P., Marazzini L.: Haemorheology in hypertension — Clin. Hemorheol.6, 576, 1986.
Lowe G. D. O.: Blood rheology in arterial disease — Clin. Sci.71, 137, 1986.
Maeda N., Shiga T.: Opposite effect of albumin on the erythrocyte aggregation induced by immunoglobulin G and fibrinogen — Biochim. biophys. Acta (Amst.)855, 127, 1986.
National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance — Diabetes28, 1039, 1979.
Petralito A., Malatino S. L., Fiore C. A.: Erythrocyte aggregation in different stages of arterial hypertension — Thromb. Haemostas.51, 555, 1985.
Reid H. L., Barnes A. J., Lock P. J., Dormandy J. A., Dormandy T. L.: A simple method for measuring erythrocyte deformability — J. clin. Pathol.29, 855, 1976.
Reisin E., Abel R., Modan M., Silverberg D. S., Eliahou H. E., Modan B.: Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients — New Engl. J. Med.298, 1, 1978.
Schmid-Schombein H., Gallash G., Volger F., Klose H. J.: Microrheology and protein chemistry of pathological red cell aggregation (blood sludge) studiedin vitro — Biorheology10, 213, 1973.
Skulskii I. A., Manninen V.: Interaction between propranolol and electron donors in altering the calcium ion-dependent potassium ion-permeability of the human red blood cell membrane — Acta physiol. scand.120, 329, 1984.
Spurk P., Gerlach A., Angelkort B.: Arterial hypertension and hemorheology — the influence of Triamteren-Hydrochlorothizid — Clin. Hemorheol.7, 439, 1987.
Stolz J. F.: Cardiovascular disease, risk factors and hemorheological parameters — Clin. Hemorheol.3, 257, 1981.
Tobian L.: Hypertension and obesity — New Engl. J. Med.298, 46, 1978.
Tuck M. L., Sowers J., Dornfeld L., Kledzik G., Maxwell M.: The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients — New Engl. J. Med.304, 930, 1981.
Weihmayr T. H., Ernst E., Matrai A., Paulsen F.: Blood rheology in untreated essential hypertension — Clin. Hemorheol.7, 457, 1987.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gelmini, G., Coiro, V., Manotti, C. et al. Effect of diet and weight loss on whole blood filterability and plasma fibrinogen values in hypertensive obese postmenopausal women. Acta diabet. lat 26, 329–335 (1989). https://doi.org/10.1007/BF02624645
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02624645