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Prediction of the chromatographic behaviour for a series of diuretic compounds

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Summary

The proportion of organic modifier and the pH of the acetonitrile-water mixtures used as mobile phases were optimized in order to separate a group of diuretic compounds covering a wide range of physyco-chemical properties. The Linear Solvation Energy Relationship (LSER) formalism based either on the multiparameter π*, β and α scales or the single solvent polarity parameterE NT , have been used to predict their chromatographic behaviour as a function of the percentage of acetonitrile in the eluent. Moreover, correlation established between retention and pH of the aqueous-organic mobile phases have been used to predict the chromatographic behaviour of the diuretic compounds studied as a function of the eluent pH. Linear correlation between a function of the eluent pH. Linear correlation between the chromatographic retention and theE NT polarity parameter of mobile phases containing different percentages of organic modifier has been obtained Based on the knowledge of the acid-base dissociation constant the relation between retention and mobile phase pH has also been linearized. These relationship allowed an important reduction of the experimental retention data needed for developing a given separation and a great improvement in chromatographic optimization schemes.

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Authors and Affiliations

  1. Departament de Química Analítica, Universitat de Barcelona, Diagonal, 647, 08028, Barcelona, Spain

    J. Barbosa, R. Bergés & V. Sanz-Nebot

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  1. J. Barbosa
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  2. R. Bergés
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  3. V. Sanz-Nebot
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Barbosa, J., Bergés, R. & Sanz-Nebot, V. Prediction of the chromatographic behaviour for a series of diuretic compounds. Chromatographia 51, 417–427 (2000). https://doi.org/10.1007/BF02490478

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  • DOI: https://doi.org/10.1007/BF02490478

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