Abstract
The development of postoperative intraperitoneal adhesions continues to be a major concern for surgeons. The purpose of this study was to establish a postoperative adhesion model in rats, and to assess the effectiveness of tranilast (N-(3′,4′-dimethoxycinnamoyl)anthranilic acid) in preventing postoperative adhesion formation. The adhesion model was established in 12 male Donryu rats. This involved two essential factors, drying and bleeding. Another 22 male Donryu rats were used to study the prevention of intraperitoneal adhesions. Tranilast was administered orally pre- and postoperatively. Adhesion strength was evaluated by grading, and basic fibroblast growth factor (bFGF) and transforming growth factor-beta-1 (TGF-β1) concentration were measured. Post-operative intraperitoneal adhesions were seen in all rats, but the adhesions in the tranilast group were significantly less severe than those in the control group. Serum bFGF and TGF-β1 levels in the tranilast group were lower at the time of surgery than those in the control group, and bFGF levels were lower at the endpoint of this study in the tranilast group than in the control group. The TGF-β1 levels at the end-point did not differ between the two groups. These findings demonstrated that tranilast significantly reduced postoperative intraperitoneal adhesion formation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Menzies D (1993) Postoperative adhesions: their treatment and relevance in clinical practice. Ann R Coll Surg Engl 75:147–153
Robbins GF, Brunshwig A, Foote FW (1949) Deperitonealization: clinical and experimental observations. Ann Surg 130:466–479
Ellis H (1962) The aetiology of postoperative abdominal adhesions. Br J Surg 50:10–16
Belzer FO (1967) The role of venous obstruction in the formation of intra-abdominal adhesions; an experimental study. Br J Surg 54:189–190
Ryan GB, Grobety J, Majno G (1971) Postoperative peritoneal adhesions. A study of mechanisms. Am J Pathol 65:117–138
Isaji M, Nakajoh M, Naito J (1987) Selective inhibition of collagen accumulation by n-(3,4-dimethoxycinnamoyl)antheranilic acid (n-5′) in granulation tissue. Biochem Pharmacol 36:469–474
Suzawa H, Kikuchi S, Ichikawa K, Arai N, Tazawa S, Tsuchiya O, Momose Y, Shibata N, Sugimoto C, Hamano S, Komatsu H, Miyata H (1992) Effect of tranilast, an anti-allergic drug, on carrageenin-induced granulation and capillary permiability in rats (in Japanese with English abstract). Nippon Yakuri Gakkai Zasshi (Folia Pharmacol Japan) 99:241–246
Yano H, Mizote H, Shindo N, Yoshinari M, Nohtomi M, Kaida S, Wakisaka J (1976) Studies on developmental mechanism of postoperative intestinal adhesion: an electron microscopical observation (in Japanese). Nippon Shokaki Geka Gakkai Zasshi (Jpn J Gastroenterol Surg) 9:865–873
Buckman RF, Woods M, Sargent L, Gervin AS (1976) A unifying pathogenetic mechanism in the etiology of intraperitoneal adhesions. J Surg Res 20:1–5
Thompson JN, Paterson-Brown S, Harbourne T, Whawell SA, Kalodiki E, Dudley HAF (1989) Reduced human peritoneal plasminogen activating activity: possible mechanism of adhesion formation. Br J Surg 76:382–384
Dörr PJ, Vemer HM, Brommer EJP, Willemsen WNP, Veldhuizen RW, Rolland R (1990) Prevention of postoperative adhesions by tissue-type plasminogen activator (t-pa) in the rabbit. Eur J Obstet Repord Biol 37:287–291
Menzies D, Ellis H (1991) The role of plasminogen activator in adhesion prevention. Surg Gynecol Obstet 172:362–366
Suzawa H, Kikuchi S, Arai N, Koda A (1992) The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts. Jpn J Pharmacol 60:91–96
Nakamura K, Nanjou F, Yoshii M (1988) An experimental and clinical study on inhibition of tendon adhesion by tranilast (in Japanese with English abstract). Nippon Teno Geka Gakkai Zasshi (J Jpn Soc Surg Hand) 5:189–193
Suzawa H, Kikuchi S, Ichikawa K (1992) Inhibitory effect of an antiallergic drug, tranilast, on the production of cytokines (in Japanese with English abstract). Oyo Yakuri (Pharmacometrics) 43:409–414
Bennett NT, Schultz GS (1993) Growth factors and wound healing: biochemical properties of growth factors and their receptors. Am J Surg 165:728–737
Kennedy R, Costain DJ, McAlister VC, Lee TDG (1996) Prevention of experimental postoperative peritoneal adhesions by N,O-carboxymethyl chytosan. Surgery 120:866–870
Costain DJ, Kennedy R, Ciona C, McAlister VC, Lee TDG (1997) Prevention of postsurgical adhesions with N,O-carboxymethyl chytosan: examination of the most efficacious preparation and the effect of N,O-carboxymethyl chytosan on postsurgical healing. Surgery 121:314–319
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Adachi, S., Maruyama, T., Kondo, T. et al. The prevention of postoperative intraperitoneal adhesions by tranilast:N-(3′,4′-dimethoxycinnamoyl)anthranilic acid. Surg Today 29, 51–54 (1999). https://doi.org/10.1007/BF02482970
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02482970