Abstract
We investigated the expression of transforming growth factors (TGFs), platelet-derived growth factor (PDGF), progesterone receptor (PgR), and c-myc in 20 cases of meningioma of various grades: 17 benign, 2 atypical, and 1 anaplastic. All cases of atypical and anaplastic meningioma were positive for c-myc, whereas all 17 benign meningiomas were negative for c-myc immunostaining. Expression of TGF-α, TGF-β, and PDGF-BB proteins was seen in more than 80% of the meningioma cases and was not restricted to their histological grade of meningioma. PgR was expressed mainly in benign meningiomas. Moreover, the cells expressing c-myc protein were not usually stained by MIB-1. These results indicate that c-myc does not directly work on the proliferation of meningioma cells, and even in homogeneous meningioma cells, there may be many functional variations that lead the meningioma cells to their growth.
Similar content being viewed by others
References
Jääskeläinen J, Haltia M, Servo A (1986) Atypical and anaplastic meningiomas: radiology, surgery, radiotherapy, and outcome. Surg Neurol 25:233–242
Mahmood A, Caccamo DV, Tomecek FJ, et al (1993) Atypical and malignant meningiomas: a clinicopathological review. Neurosurgery 33:955–963
Nagashima G, Aoyagi M, Wakimoto H, et al (1995) Immunohistochemical detection of progesterone receptors and the correlation with Ki-67 labelling indices in paraffin-embedded sections of meningiomas. Neurosurgery 37:478–483
Nagashima G, Aoyagi M, Yamamoto M, et al (1999) p53 overexpression and proliferative potential in malignant meningiomas. Acta Neurochir (Wien) 141:53–61
Kleihues P, Burger PC, Scheithauer BW (1993) Histological typing of tumours of the central nervous system. Springer-Verlag, New York
Shin RW, Iwaki T, Kitamoto T, et al (1991) Methods in laboratory investigation, hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues. Lab Invest 64:693–702
Wakimoto H, Aoyagi M, Nakayama T, et al (1996) Prognostic significance of Ki-67 labeling indices obtained using MIB-1 monoclonal antibody in patients with supratentorial astrocytomas. Cancer 77:373–380
Alitalo K, Koskinen P, Makela TP, et al (1987) myc oncogenes: activation and amplification. Biochem Biophys Acta 907:1–32
Luscher B, Eisenman RN (1990) New light on Myc and Myb. Part I. Myc. Genes Dev 4:2025–2035
Meichle A, Philipp A, Eilers M (1992) The functions of Myc proteins. Biochem Biophys Acta 1114:129–146
Detta A, Kenny BG, Smith C, et al (1993) Correlation of protooncogene expression and proliferation in meningiomas. Neurosurgery 33:1065–1074
Kazumoto K, Tamura M, Hoshino H, et al (1990) Enhanced expression of the sis and c-myc oncogenes in human meningiomas. J Neurosurg 72:786–791
Tanaka K, Sato C, Maeda Y, et al (1989) Establishment of a human malignant meningioma cell line with amplified c-myc oncogene. Cancer 64:2243–2249
Johnson MD, Federspiel CF, Gold LI, et al (1992) Transforming growth factor-beta and transforming growth factor beta-receptor expression in meningioma cells. Am J Pathol 141:633–642
Nitta T, Sato K, Okumura K (1991) Transforming growth factor (TGF)-beta like activity of intracranial meningioma and its effect on cell growth. J Neurol Sci 101:19–23
Hsu DW, Efird JT, Hedley-Whyte ET (1998) MIB-1 (Ki-67) index and transforming growth factor-alpha (TGF alpha) immunoreactivity are significant prognostic predictors for meningiomas. Neuropathol Appl Neurobiol 24:441–452
Black PM, Carroll R, Glowacka D, et al (1994) Platelet-derived growth factor expression and stimulation In human meningiomas. J Neurosurg 81:388–393
Asai J, Suzuki R, Fujimoto T, et al (1999) Fluorescence automatic cell sorter and immunohistochemical investigation of CD68-positive cells in meningioma. Clin Neurol Neurosurg 101:229–234
Maxwell M, Galanopoulos T, Hedley-Whyte ET, et al (1990) Human meningiomas co-express platelet-derived growth factor (PDGF) and PDGF-receptor genes and their protein products. Int J Cancer 46:16–21
Bissonnette RP, Echeverri F, Mahboubi A, et al (1992) Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 359:552–554
Fanidi A, Harrington EA, Evan GI (1992) Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature, 359:554–556
Shi Y, Glynn JM, Guilbert LJ, et al (1992) Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257:212–214
Evan GI, Hancock D, Bennet M, et al (1994) c-myc, In: Mihich E, Schimke RT (eds) Apoptosis. Plenum Press, New York, pp 63–84
Strasser A, Harris AW, Bath ML, et al (1990) Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 348:331–333
Spencer CA, Groudine M (1991) Control of c-myc regulation in normal and neoplastic cell. Adv Cancer Res 56:1–48
Perry A, Jenkins RB, Dahl RJ, et al (1996) Cytogenetic analysis of aggressive meningiomas: possible diagnostic and prognostic implications. Cancer 77:2567–2573
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nagashima, G., Asai, Ji., Suzuki, R. et al. Different distribution of c-myc and MIB-1 positive cells in malignant meningiomas with reference to TGFs, PDGF, and PgR expression. Brain Tumor Pathol 18, 1–5 (2001). https://doi.org/10.1007/BF02478918
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02478918