Summary
Fat tissue from the genetically obese mouse (C57BL/6J ob/ob) and its lean littermate (+/ ?) was transplanted into lean hosts (+/+). Chemical induced obesity in the host mice caused no greater increase in the size of ‘obese’ fat cells than it did in the size of ‘lean’ fat cells. ‘Obese’ fat cells, therefore, have no innate capacity for increased fat storage.
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Ashwell, M., Meade, C.J. Obesity: Do fat cells from genetically obese mice (C57BL/6J ob/ob) have an innate capacity for increased fat storage?. Diabetologia 15, 465–470 (1978). https://doi.org/10.1007/BF02342871
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DOI: https://doi.org/10.1007/BF02342871