Abstract
3 peptic ulcer patients, treated for a few weeks with Trithiozine, developed polyneuropathy. The histopathological patterns in the 2 patients in whom sural nerve biopsy was done presented wallerian degeneration of the axons of the myelinated fibers, especially those of larger caliber. The evidence for a iatrogenic toxic etiology is discussed.
Sommario
Gli Autori descrivono tre casi di polineuropatia insorta in pazienti ulcerosi e trattati per alcune settimane con Tritiozina.
I quadri istopatologici osservati in due pazienti in cui si è ottenuta biopsia del nervo surale, evidenziano una sofferenza assonale del tipo della degenerazione walleriana a carico delle fibre mieliniche, specie di maggior calibro.
Vengono discussi gli elementi a favore di una origine tossico-iatrogena del quadro clinico osservato.
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References
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Crespi, V., Petruccioli Pizzini, M.G., Tredici, G. et al. Trithiozine polyneuropathy: clinical, neurophysiological and histopathological study of three cases. Ital J Neuro Sci 2, 291–295 (1981). https://doi.org/10.1007/BF02335410
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DOI: https://doi.org/10.1007/BF02335410