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Synthesis of substituted 3-aminospiro-4-but-2-enolides

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Previously unknown 3-N-alkylamino-, 3-N,N-dialkylamino-4-but-2-enolides containing spirocyclic moiety have been synthesized by nucleophilic addition of amines at the triple bond of methyl ester of β-(1-hydroxycyclohexyl)propiolic acid or by the reaction of amines with the corresponding 3-methoxy-4-but-2-enolide.

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Authors
  1. M. V. Mavrov
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  2. N. I. Simirskaya
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Additional information

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 117913, Russia. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1330–1335, October, 1999.

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Mavrov, M.V., Simirskaya, N.I. Synthesis of substituted 3-aminospiro-4-but-2-enolides. Chem Heterocycl Compd 35, 1150–1155 (1999). https://doi.org/10.1007/BF02323371

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  • DOI: https://doi.org/10.1007/BF02323371

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