Summary
The capability of elution-elution multi-dimensional liquid chromatography was investigated. A “column scaling” approach was evaluated for the quantification of low-molecular-weight additives in cellulose acetate. A small-bore (1-mm i.d.) gel-permeation column was used to separate the higher-molecular-weight polymer from the lower-molecular-weight components. Once separated these additives were transferred to a C18 reversed-phase column via a switching valve. The reversed-phase system successfully separated and quantified individual additives.
Analysis time for an ultraviolet inhibitor, Tinuvin®P, in cellulose acetate, including re-equilibration, was approximately 30 minutes. Both accuracy and precision were good. Precision over a three day period was about 1.5%.
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Floyd, T.R. Use of two-dimensional liquid chromatography in the analysis of additives in cellulose acetate polymer. Chromatographia 25, 791–796 (1988). https://doi.org/10.1007/BF02262086
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DOI: https://doi.org/10.1007/BF02262086