Abstract
The effects of subcutaneous administration of leuenkephalin (LEU-E) (10, 100 and 300 µg/kg) and LEU-E (100 µg/kg) plus naloxone (2.5 mg/kg) on ethanol preference and fluid intake have been investigated in rats. Under our procedural conditions, rats develop ethanol preference through forced ethanol drinking (conditioning session). Preconditioning administration of LEU-E induced a reduction of later ethanol preference. Post-conditioning administration of LEU-E (10 and 100 µg/kg) also attenuated the development of ethanol preference. NX antagonized the effects of LEU-E on ethanol preference and fluid consumption in the two experimental procedures used, indicating an involvement of opioid receptors in the LEU-E-induced impairment of the acquisition of ethanol preference.
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Supported by a PFPI fellowship from the MEC
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Sandi, C., Borrell, J. & Guaza, C. Administration of leu-enkephalin impairs the acquisition of preference for ethanol. Psychopharmacology 100, 350–354 (1990). https://doi.org/10.1007/BF02244605
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DOI: https://doi.org/10.1007/BF02244605