Summary
Periodontitis is an excellent model of local tissue destruction due to the uncontrolled action of host and microbial proteinases. Although host enzymes are responsible for direct degradation of connective tissue, proteinases from the periodontopathogenic bacteriumPorphyromonas gingivalis are able to activate the kallikrein/kinin cascade, disrupt coagulation, and activate complement-mediated chemotaxis. Since the hallmarks of adult onset of periodontitis include infection by this pathogen, bleeding, increased crevicular flow, and neutrophil accumulation, investigations of this disease at a biochemical level indicate a major role for bacterial proteinases in infections byP. gingivalis.
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Moore, W.E.C., Moore, L.V.H. and Cato, E.P., U.S. Fed. Culture Collect. Newslett., 18 (1988) 7.
Nyvad, B. and Kilian, M., Scand. J. Dent. Res., 95 (1987) 369.
Löe, H., Theilade, E. and Jensen, S.B., J. Periodontol., 36 (1965) 177.
Moore, L.V.H., Moore, W.E.C., Cato, E.P., Smibert, R.M., Burmeister, J.A., Best, A.M. and Ranney, R.R., J. Dent. Res., 66 (1987) 989.
Moore, W.E.C., J. Periodontal Res., 22 (1987) 335.
Williams, D.M., Hughes, F.J., Odell, E.W. and Farthing, P.M., Pathology of Periodontal Disease, Oxford University Press, Oxford, 1992.
Lung, N.P., Arch. Oral Biol., 35 (1990) 9S.
Slots, J. and Listgarten, M.A., J. Clin. Periodontol., 13 (1988) 570.
Slots, J., Bragd, L., Wikström, M. and Dahlen, G., J. Clin. Periodontol., 15 (1988) 85.
Holt, S.C., Ebersole, J., Felton, J., Brunsvold, M. and Kornmann, K.S., Science, 239 (1987) 55.
Lamster, I.B., Smith, Q.T., Celenti, R.S., Singer, R.E. and Grbic, J.T., J. Periodontol., 65 (1994) 511.
Mayrand, D. and Holt, S.C., Microbiol. Rev., 52 (1988) 134.
Holt, S.C. and Brumante, T.E., Crit. Rev. Oral Biol. Med., 2 (1991) 177.
Kolenbrander, P.E., In Dworkin, M. (Ed.) Microbial Cell-Cell Interactions, American Society for Microbiology, Washington, DC, 1991, pp. 303–329.
Sundqvist, G., FEMS Immunol. Med. Microbiol., 6 (1993) 125.
Cutler, C.W., Kalmar, J.R. and Genco, C.A., Trends Microbiol. Sci., 3 (1995) 45.
Nilsson, T., Carlsson, J. and Sundqvist, G., Infect. Immun., 50 (1985) 467.
Carlsson, J., Herrmann, B.F., Hofling, J.F. and Sundqvist, G.K., Infect. Immun., 43 (1984) 644.
Sato, M., Otsuka, M., Maehara, R., Endo, J. and Nakamura, R., Arch. Oral Biol., 32 (1987) 235.
Grenier, D., Infect. Immun., 60 (1992) 1854.
Sundqvist, G., Carlsson, J., Herrmann, B. and Tarnvik, A., J. Med. Microbiol., 19 (1985) 85.
Grenier, D., Mayrand, D. and McBride, B.C., Oral Microbiol. Immunol., 4 (1989) 12.
Fishburn, C.S., Slaney, J.M., Carman, R.J. and Curtis, M.A., Oral Microbiol. Immunol., 6 (1991) 209.
Cutler, C.W., Arnold, R.R. and Schenkein, H.A., J. Immunol., 151 (1993) 7016.
Carlsson, J., Hofling, J.F. and Sundqvist, G.K., J. Med. Microbiol., 18 (1984) 39.
Wikström, M.B., Dahlen, G. and Linde, A., J. Clin. Microbiol., 17 (1983) 759.
Scott, C.F., Whitaker, E.J., Hammond, B.F. and Colman, R.W., J. Biol. Chem., 268 (1993) 7935.
Lantz, M.S., Rowland, R.W., Switalski, L.M. and Hook, M., Infect. Immun., 54 (1986) 654.
Sundqvist, G., Bengtson, A. and Carlsson, J., Oral Microbiol. Immunol., 3 (1988) 103.
Schenkein, H.A. and Berry, C.R., J. Periodontal Res., 23 (1988) 308.
Schenkein, H.A., Oral Microbiol. Immunol., 6 (1991) 216.
Schenkein, H.A., J. Periodontal Res., 23 (1988) 187.
Wingrove, J.A., DiScipio, R.G., Chen, Z., Potempa, J., Travis, J. and Hugli, T.E., J. Biol. Chem., 267 (1992) 18902.
Imamura, T., Potempa, J., Pike, R.N. and Travis, J., Infect. Immun., 63 (1995) 1999.
Imamura, T., Pike, R.N., Potempa, J. and Travis, J., J. Clin. Invest., 94 (1994) 361.
Hinode, D., Nagata, A., Ichimiya, S., Hayashi, H., Morioka, M. and Nakamura, R., Arch. Oral Biol., 37 (1992) 859.
Wikström, M. and Linde, A., Infect. Immun., 51 (1986) 707.
Uitto, V.-J., Haapasalo, M., Laakso, T. and Salo, T., Oral Microbiol. Immunol., 3 (1988) 97.
Smalley, J.W., Birss, A.J. and Shuttleworth, C.A., Arch. Oral Biol., 33 (1988) 323.
Lantz, M.S., Allen, R.D., Duck, L.W., Blume, J.L., Switalski, L.M. and Hook, M., J. Bacteriol., 173 (1991) 4263.
Uitto, V.-J., Larjava, H., Heino, J. and Sorsa, T., Infect. Immun., 57 (1989) 213.
Gibbons, R.J., Hay, D.I., Childs III, W.C. and Davis, G., Arch. Oral Biol., 35 (1990) 107S.
Otsuka, M., Endo, J., Hinode, D., Nagata, A., Maehara, R., Sato, M. and Nakamura, R., J. Periodontal Res., 22 (1987) 491.
Odell, E.W. and Wu, P.J., Arch. Oral Biol., 37 (1992) 597.
Sorsa, T., Ingman, T., Suomalainen, K., Haapasalo, M., Konttinen, Y.T., Lindy, O., Saari, H. and Uitto, V.-J., Infect. Immun., 60 (1992) 4491.
Curtis, M.A., Macey, M., Slaney, J.M. and Howells, G.L., FEMS Microbiol. Lett., 110 (1993) 167.
Lala, A., Amano, A., Sojar, H.T., Radel, S.J. and De Nardin, E., Biochem. Biophys. Res. Commun., 199 (1994) 1489.
Bedi, G.S. and Williams, T., J. Biol. Chem., 269 (1994) 599.
Kadowaki, T., Yoneda, M., Okamoto, K., Maeda, K. and Yamamoto, K., J. Biol. Chem., 269 (1994) 21371.
Lawson, D.A. and Meyer, T.F., Infect. Immun., 60 (1992) 1524.
Kato, T., Takahashi, N. and Kuramitsu, H.K., J. Bacteriol., 174 (1992) 3889.
Birkedal-Hansen, H., Taylor, R.E., Zambon, J.J., Barwa, P.K. and Neiders, M.E., J. Periodontal Res., 23 (1988) 258.
Gangbar, S., Overall, C.M., McCulloch, C.A.G. and Sodek, J., J. Periodontal Res., 25 (1990) 257.
Overall, C.M., Sodek, J., McCulloch, C.A.G. and Birek, P., Infect. Immun., 59 (1991) 4687.
Grenier, D., Chao, G. and McBride, B.C., Infect. Immun., 57 (1989) 95.
Wikström, M., Potempa, J., Polanowski, A., Travis, J. and Renvert, S., J. Periodontol., 65 (1994) 47.
Yoshimura, F., Nishikata, M., Suzuki, T., Hoover, C.I. and Newbrun, E., Arch. Oral Biol., 29 (1984) 559.
Fujimura, S. and Nakamura, T., Infect. Immun., 55 (1987) 716.
Ono, M., Okuda, K. and Takazoe, I., Oral Microbiol. Immunol., 2 (1987) 77.
Sorsa, T., Uitto, V.-J., Suomalainen, K., Turto, H. and Lindy, S., J. Periodontal Res., 22 (1987) 375.
Tsutsui, H., Kinouchi, T., Wakano, Y. and Ohnishi, Y., Infect. Immun., 55 (1987) 420.
Fujimura, S. and Nakamura, T., Oral Microbiol. Immunol., 5 (1990) 360.
Hinode, D., Hayashi, H. and Nakamura, R., Infect. Immun., 59 (1991) 3060.
Nishikata, M., Kanehira, T., Oh, H., Tani, H., Tazaki, M. and Kuboki, Y., Biochem. Biophys. Res. Commun., 174 (1991) 625.
Nishikata, M. and Yoshimura, F., Biochem. Biophys. Res. Commun., 178 (1991) 336.
Shah, H.N., Gharbia, S.E., Kowlessur, D., Wilkie, E. and Brocklehurst, K., Microb. Ecol. Health Dis., 4 (1991) 319.
Fujimura, S., Shibata, Y. and Nakamura, T., FEMS Microbiol. Lett., 113 (1993) 133.
Chen, Z.X., Potempa, J., Polanowski, A., Wikström, M. and Travis, J., J. Biol. Chem., 267 (1992) 18896.
Curtis, M.A., Ramakrishnan, M. and Slaney, J.M., J. Gen. Microbiol., 139 (1993) 949.
Fujimura, S., Shibata, Y. and Nakamura, T., Oral Microbiol. Immunol., 7 (1992) 212.
Pike, R., McGraw, W., Potempa, J. and Travis, J., J. Biol. Chem., 269 (1994) 406.
Ciborowski, P., Nishikata, M., Allen, R.D. and Lantz, M.S., J. Bacteriol., 176 (1994) 4549.
Pavloff, N., Potempa, J., Pike, R.N., Prochazka, V., Kiefer, M.C., Travis, J. and Barr, P.J., J. Biol. Chem., 270 (1995) 1007.
Potempa, J., Pike, R. and Travis, J., Infect. Immun., 63 (1995) 1176.
Grenier, D. and Mayrand, D., Infect. Immun., 55 (1987) 111.
Minhas, T. and Greenman, J., J. Gen. Microbiol., 137 (1989) 557.
Smalley, J.W. and Birss, J., J. Gen. Microbiol., 133 (1987) 2883.
Smalley, J.W. and Birss, J., Oral Microbiol. Immunol., 6 (1991) 202.
Smith, A.J., Minhas, T., Greenman, J. and Embery, G., Microbios, 73 (1993) 185.
Klauser, T., Pohlner, J. and Meyer, T.F., BioEssays, 15 (1993) 799.
Pugsley, A.P., Microbiol. Rev., 57 (1993) 50.
Okamoto, K., Misumi, Y., Kadowaki, T., Yoneda, M., Yamamoto, K. and Ikehara, Y., Arch. Biochem. Biophys., 316 (1995) 917.
Cox, S.W. and Eley, B.M., J. Clin. Periodontol., 19 (1992) 333.
Gustafsson, A., Åsman, B., Bergström, K. and Söder, P.-Ö., J. Clin. Periodontol., 19 (1992) 535.
Giannopoulou, C., Andersen, E., Demeurisse, C. and Cimasoni, G., J. Dent. Res., 71 (1992) 359.
Shah, H.N. and Gharbia, S.E., FEMS Microbiol. Lett., 61 (1989) 213.
Fletcher, H.M., Schenkein, H.A., Morgan, R.M., Bailey, K.A., Berry, C.R. and Macrina, F.L., Infect. Immun., 63 (1995) 1521.
Medlicott, N.J., Rathbone, M.J., Tucker, I.G. and Holborow, D.W., Adv. Drug Deliv. Rev., 13 (1994) 181.
Kornman, K.S., J. Periodontol., 64 (1993) 782.
Genco, R.J., J. Periodontol., 63 (1992) 338.
Birkedal-Hansen, H., J. Periodontal Res., 28 (1993) 500.
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Potempa, J., Pike, R. & Travis, J. Host andPorphyromonas gingivalis proteinases in periodontitis: A biochemical model of infection and tissue destruction. Perspectives in Drug Discovery and Design 2, 445–458 (1995). https://doi.org/10.1007/BF02172037
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DOI: https://doi.org/10.1007/BF02172037