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Permeability transition pore of the inner mitochondrial membrane can operate in two open states with different selectivities

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Abstract

Prooxidants induce release of Ca2+ from mitochondria through the giant solute pore in the mitochondrial inner membrane. However, under appropriate conditions prooxidants can induce Ca2+ release without inducing a nonspecific permeability change. Prooxidant-induced release of Ca2+ isselective. Presumably, this is the result of the operation of a permeability pathway for H+ coupled to the reversal of the Ca2+ uniporter, the latter generating the selectivity. The solute pore and prooxidant-induced Ca2+-specific pathways exhibit common sensitivities to a set of inhibitors and activators. It is proposed that the pore can operate in two open states: (1) permeable to H+ only and (2) permeable to solutes of Mr<1500. Under some conditions, prooxidants induce the H+-selective state which, in turn, collapses the inner membrane potential and permits selective loss of Ca2+ via the Ca2+ uniporter.

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Authors and Affiliations

  1. A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119899, Moscow, Russia

    Sergei A. Novgorodov

  2. Department of Biophysics, Biological Faculty, Moscow State University, 119899, Moscow, Russia

    Tatyana I. Gudz

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  1. Sergei A. Novgorodov
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  2. Tatyana I. Gudz
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Novgorodov, S.A., Gudz, T.I. Permeability transition pore of the inner mitochondrial membrane can operate in two open states with different selectivities. J Bioenerg Biomembr 28, 139–146 (1996). https://doi.org/10.1007/BF02110644

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  • DOI: https://doi.org/10.1007/BF02110644

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