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Bone loss in patients with inflammatory bowel disease: A prospective study

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Abstract

To assess the rate of bone loss in patients with inflammatory bowel disease, we prospectively studied 35 patients (17 women) aged 36±13 (range 17–60) years, 14 of whom had Crohn's disease and 21 with ulcerative colitis (including 12 with ileoanal anastomosis). Bone mineral density was measured by dual-energy X-ray absorptiometry at the lumbar spine and femoral neck. The follow-up was 19±8 months. During this period, 14 patients received oral steroids. Lumbar bone density changes expressed as a percentage per year were −3.1±4.9%, −6.4±7.5% and +2.0±4.0% in Crohn's disease and ulcerative colitis without and with ileoanal anastomosis respectively (p=0.007). The same pattern was observed at the femoral neck. Mean annual lumbar bone density changes were −6.2±7.0% and +0.9±3.9% in patients with and without steroids during follow-up (p=0.002). We conclude that patients with inflammatory bowel disease are at risk of lumbar and femoral bone loss. However, bone loss is not observed in patients with ileoanal anastomosis.

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Authors and Affiliations

  1. Clinique de Rhumatologie, Hôpital Cochin, Univeristé René Descartes, 27 rue du Faubourg Saint Jacques, F-75014, Paris, France

    C. Roux MD, S. Kolta, M. Dougados & B. Amor

  2. Service d'Hépato-Gastro-Entérologie, Hôpital Cochin, Université René Descartes, 27 rue du Faubourg Saint Jacques, F-75014, Paris, France

    V. Abitbol, S. Chaussade & D. Couturier

  3. Laboratoire de Biochimie, Université Pierre et Marie Curie, Paris, France

    S. Guillemant

Authors
  1. C. Roux MD
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  2. V. Abitbol
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  3. S. Chaussade
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  4. S. Kolta
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  5. S. Guillemant
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  6. M. Dougados
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  7. B. Amor
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  8. D. Couturier
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Roux, C., Abitbol, V., Chaussade, S. et al. Bone loss in patients with inflammatory bowel disease: A prospective study. Osteoporosis Int 5, 156–160 (1995). https://doi.org/10.1007/BF02106094

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  • DOI: https://doi.org/10.1007/BF02106094

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