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Influence of spasmolytic analgesics on motility of sphincter of oddi

  • Pancreatic And Biliary Disorders
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Abstract

The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg;N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdominal pain. Basal sphincter pressure and sphincter motility were measured for a 5-min period after treatment by endoscopic manometry. Nitroglycerin and dipyrone both caused a significant fall in basal sphincter pressure, whileN-butylscopolamine and nitroglycerin produced a significant decrease in contraction frequency. Therefore, dipyrone, in contrast to tramadol and indomethacin, exhibits spasmolytic activity in addition to analgesia in biliary pain.

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References

  1. Eigler FW: Schmerz und akutes Abdomen.In Gastroenterologie. H Goebell (ed). Munich Urban & Schwarzenberg, 1992

  2. Delmont J, Harris AG: Limitations of endoscopic manometry of the sphincter of Oddi.In New York, Raven Press, HJ Siegel (ed). Endoscopic Retrograde Pancreatography; 1992

    Google Scholar 

  3. Hogan WJ: Sphincter of Oddi human physiology; the manometric era. Ital J Gastroenterol 18:31–45, 1986

    Google Scholar 

  4. Staritz M, Poralla T, Ewe K, Meyer zum Büschenfelde KH: Effect of glyceryl trinitrate on sphincter of Oddi motility and baseline pressure. Gut 26:194, 1985

    PubMed  Google Scholar 

  5. Brandstätter G: Pharmacological pressure reduction in the human common bile duct. Z Gastroenterol 21:168, 1983

    PubMed  Google Scholar 

  6. Nowakowska-Dulawa E, Nowak A, Kaczor R: Effects of isosorbide dinitrate and Hymecromone on the motor activity of the sphincter of Oddi in man. World Congress of Gastroenterology, Sydney, 1990, p 160

  7. Neugebauer V, Schaible HG: Electrophysiological evidence for a spinal antinociceptive action of dipyrone. Agents Actions 41:62–70, 1994

    PubMed  Google Scholar 

  8. Mutschler E (ed): Arzneimittelwirkungen, 6. Auflage. Stuttgart, Wissenschaftliche Verlagsgesellschaft 1991

    Google Scholar 

  9. Remjan F: Intravenous indomethacin in biliary pain IRCS Med Sci 112:398–400, 1984

    Google Scholar 

  10. Corazziari E, Biliotti D: Sphincter of Oddi manometry. Gastroenterol Int 2:180–184, 1989

    Google Scholar 

  11. Nebel OT: Manometric evaluation of the papilla of Vater. Gastrointest Endosc 21:126–128, 1975

    PubMed  Google Scholar 

  12. Staritz M, Meyer zum Büschenfelde KH: Investigation of the effect of diazepam and other drugs on the sphincter of Oddi motility. Ital J Gastroenterol 18:41, 1986

    Google Scholar 

  13. Ponce J, Garrigues V, Sala T, Pertejo V, Berenguer J: Diazepam does not modify the motility of the sphincter of Oddi. Endoscopy 20:87, 1988

    PubMed  Google Scholar 

  14. Funch-Jensen P: Sphincter of Oddi motility. Acta Chir Scand Suppl 553, 1990

  15. Allescher HD, Neuhaus H, Hagenmüller F, Classen M: Effect ofN-butylscopolamine on sphincter of Oddi motility in patients during routine ERCP—a manometric study. Endoscopy 20:73, 1988

    PubMed  Google Scholar 

  16. Kaczor R, Nowakowska-Dulawa E, Rybicka J: Effects of Scopolamine butylbromide, papaverine and glucagon on the sphincter of Oddi motility. Endoscopy 20:73, 1988

    PubMed  Google Scholar 

  17. Staritz M, Poralla T, Mann M, Meyer zum Büschenfelde KH: Effect of modern analgesic drugs (tramadol, pentazocine and buprenorphine) on the bile duct sphincter in man. Gut 27:567–569, 1986

    PubMed  Google Scholar 

  18. Binmoeller KF, Dumas R, Harris AG, Delmont JP: Effect of somatostatin analog octreotide on human sphincter of Oddi. Dig Dis Sci 37(5):773–777, 1992

    PubMed  Google Scholar 

  19. Cuer JC, Dapoigny M, Bommelaer G: The effect of midazolam on motility of the sphincter of Oddi in human subjects. Endoscopy 25:384–386, 1993

    PubMed  Google Scholar 

  20. Biliotti D, Habib FI, De Masi E, Primerano L, Pallotta N, Corazziari E: Effect of glucagon on sphincter of Oddi motor activity. Digestion 43:185–189, 1989

    PubMed  Google Scholar 

  21. Cuer JC, Dapoigny M, Ajmi S, Larpent JL, Lunaud B, Ferrier C, Bommelaer G: Effects of buprenorphine on motor activity of the sphincter of Oddi in man. Eur J Clin Pharmacol 36:203–204, 1989

    PubMed  Google Scholar 

  22. Thune A, Saccone GTP, Scicchitano JP, Toouli J: Distension of the gall bladder inhibits Sphincter of Oddi motility in humans. Gut 32:690–693, 1991

    PubMed  Google Scholar 

  23. Rolny P, Funch-Jensen P, Kruse A, Thommesen P: Effect of cholecystectomy on the relationship between hydrostatic common bile duct pressure and Sphincter of Oddi motility. Endoscopy 23:111–113, 1991

    PubMed  Google Scholar 

  24. Guelrud M, Mendoza S, Rossiter G, Villegas MI: Sphincter of Oddi manometry in healthy volunteers. Dig Dis Sci 35(1):38–46, 1990

    PubMed  Google Scholar 

  25. Games PA: An improvedt table for simultaneous control ong-contrasts. J Am Stat Assoc 72:531–534, 1977

    Google Scholar 

  26. Sidak Z: Rectangular confidence regions for the means of multivariate normal distributions. J Am Stat Assoc 62:626–633, 1967

    Google Scholar 

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Authors and Affiliations

  1. From the University Clinic, Graz, Austria

    G. Brandstätter MD, S. Schinzel DiplMath & H. Wurzer MD

  2. Biometric Group VPI/Medical Department, Hoechst AG, Frankfurt/M., Germany

    G. Brandstätter MD, S. Schinzel DiplMath & H. Wurzer MD

Authors
  1. G. Brandstätter MD
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  2. S. Schinzel DiplMath
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  3. H. Wurzer MD
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Additional information

This study was sponsored by Hoechst AG, Frankfurt/M., Germany

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Brandstätter, G., Schinzel, S. & Wurzer, H. Influence of spasmolytic analgesics on motility of sphincter of oddi. Digest Dis Sci 41, 1814–1818 (1996). https://doi.org/10.1007/BF02088751

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  • DOI: https://doi.org/10.1007/BF02088751

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