Abstract
The therapeutic efficacy and safety of ciprofloxacin was studied in 30 patients withPseudomonas aeruginosa infections. In 20 patients ciprofloxacin was given alone and in 10 patients (including 8 compromized hosts) in combination with an aminoglycoside (9) or azlocillin (1). Ciprofloxacin was given in doses of 500 mg orally or 200–300 mg i. v. every 12 h. In patients receiving only ciprofloxacin clinical cure with eradication of bacteria was obtained in 15 patients (75%) with infections of bone and joint (6), skin and soft tissue (4), lung (2), middle ear (2) and CSF (1). Two patients with lymphoma andPseudomonas aeruginosa pneumonia died. In patients receiving combination therapy a definite therapeutic success was achieved in four (40%). Three patients withPseudomonas aeruginosa septicemia died. In seven patients nine bacterial strains with decreasing susceptibility of ciprofloxacin (increase in MIC from ⩽0.5μg/ml to 2–16 μg/ml) were selected (6Pseudomonas aeruginosa, 1Enterobacter cloacae, 1Serratia marcescens, 1Staphylococcus aureus). Ciprofloxacin was well tolerated. This new quinolone seems to be suitable for single drug treatment ofPseudomonas aeruginosa infections in patients with normal host defense mechanisms, while its therapeutic potential in compromized hosts requires further evaluation.
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Muytjens, H. L., van der Ros-van de Repe, J., Veldhuizen, G.: Comparative eactivities of ciprofloxacin (Bay 09867), norfloxacin, pipemidic acid, and nalidixic acid. Antimicrobial Agents and Chemotherapy 1983, 24: 302–304.
Chin, N. X., Neu, H. C.: Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria. Antimicrobial Agents and Chemotherapy 1984, 25: 319–326.
Reeves, D. S., Bywater, M. J., Holt, H. A., White, L. O.: In vitro studies with ciprofloxacin, a new 4-quinolone compound. Journal of Antimicrobial Chemotherapy 1984, 13: 333–346.
Van Caekenberghe, D. L., Pattyn, S. R.: In vitro activity of ciprofloxacin compared with those of other new fluorinated piperazinyl-substituted quinoline derivatives. Antimicrobial Agents and Chemotherapy 1984, 25: 518–521.
Schiff, J. B., Small, G. J., Pennington, J. E.: Comparative activities of ciprofloxacin, ticarcillin and tobramycin against experimentalPseudomonas aeruginosa pneumonia. Antimicrobial Agents and Chemotherapy 1984, 24: 1–4.
Crump, B., Wise, R., Dent, J.: Pharmacokinetics and tissues penetration of ciprofloxacin. Antimicrobial Agents and Chemotherapy 1983, 24: 784–786.
Wingender, W., Graefe, K. H., Gau, W., Förster, D., Beermann, D., Schacht, P.: Pharmacokinetics of ciprofloxacin after oral and intravenous administration in healthy volunteers. European Journal of Clinical Microbiology 1984, 3: 355–359.
Aronoff, G. E., Kenner, C. H., Sloan, R. S., Pottratz, S. T.: Multiple-dose ciprofloxacin kinetics in normal subjects. Clinical Pharmacology and Therapeutics 1984, 36: 384–388.
Gau, W., Ploschke, H. J., Schmidt, K., Weber, B.: Determination of ciprofloxacin (BAY O 9867) in biological fluids by high-performance liquid chromatography. Journal of Liquid Chromatography 1985, 8: 485–497.
Eron, L. J., Harvey, L., Hixon, D. L., Poretz, D. M.: Ciprofloxacin therapy of infections caused byPseudomonas aeruginosa and other resistant bacteria. Antimicrobial Agents and Chemotherapy 1985, 28: 308–310.
Brumfitt, W., Franklin, I., Grady, D., Hamilton-Miller, J. M. T., Iliffe, A.: Changes in the pharmacokinetics of ciprofloxacin and fecal flora during administration of a 7-day course to human volunteers. Antimicrobial Agents and Chemotherapy, 1984, 26: 757–761.
Gonzales, M. A., Uribe, F., Moisen, S. D., Fuster, P. A., Selen, A., Welling, P. G., Painter, B.: Multiple-dose pharmacokinetics and safety of ciprofloxacin in normal volunteers. Antimicrobial Agents and Chemotherapy 1984, 26: 741–744.
Sanders, C. C., Sanders, W. E., Goering, R. V., Werner, V.: Selection of multiple antibiotic resistance by quinolones, beta-lactams, and aminoglycosides with special reference to cross-resistance between unrelated drug classes. Antimicrobial Agents and Chemotherapy 1984, 26: 797–801.
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Follath, F., Bindschedler, M., Wenk, M. et al. Use of ciprofloxacin in the treatment ofPseudomonas aeruginosa infections. Eur. J, Clin. Microbiol. 5, 236–240 (1986). https://doi.org/10.1007/BF02013997
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DOI: https://doi.org/10.1007/BF02013997