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The microbial oxygenation of the benzylisoquinoline alkaloid laudanosine

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Summary

The microbial transformation of the benzylisoquinoline alkaloid laudanosine by a strain ofPseudomonas putida gives a metabolite in which O-demethylation of 1 methoxyl group of ring C, and introduction of 1 ketonic oxygen at C9 and 1 phenolic oxygen at ring C have occurred. Also, O-methylcoripalline is formed in this transformation.

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References

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Authors and Affiliations

  1. Istituto di Microbiologia Agraria e Tecnica dell' Università, Via Celoria 2, I-20133, Milano, Italy

    L. Canonica, G. Galliani, B. Rindone, St. Tollari, V. Andreoni & E. Galli

  2. Istituto di Chimica Organica della Facoltà di Scienze, Università degli Studi di Milano, Via G. Venezian, 21, I-20133, Milano, Italy

    L. Canonica, G. Galliani, B. Rindone, St. Tollari, V. Andreoni & E. Galli

Authors
  1. L. Canonica
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  2. G. Galliani
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  3. B. Rindone
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  4. St. Tollari
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  5. V. Andreoni
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  6. E. Galli
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Additional information

This work was supported by a CNR grant.

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Canonica, L., Galliani, G., Rindone, B. et al. The microbial oxygenation of the benzylisoquinoline alkaloid laudanosine. Experientia 39, 1273–1275 (1983). https://doi.org/10.1007/BF01990366

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  • DOI: https://doi.org/10.1007/BF01990366

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