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Role of potassium channels in the regulation of cytokine release from THP-1 cells

  • Proceedings of the Joint World Congress of the International Association of Inflammation Societies and the European Inflammation Society, Austria Center, Vienna, October 10–15, 1993
  • Inhibitors of Cytokine Generation and Action
  • Published:
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Abstract

The role of K+ channels in the regulation of cytokine release was investigated. Quinine, a non-selective K+ channel blocking agent inhibited both TNFα and IL-1β release but had non-specific effects on cell function. Glipizide and glibenclamide, inhibitors of ATP-sensitive K+ channels, reduced IL-1β release but not TNFα, whereas apamin, a selective inhibitor of low-conductance Ca2+-sensitive channels, inhibited TNFα release, potentiated IL-1β but had no effect on IL-6 or IL-8 release. These results suggest that K+ channels may differentially regulate cytokine production by THP-1 cells.

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  1. The Wellcome Foundation, Beckenham, UK

    A. M. Deakin, A. N. Payne & G. J. Blackwell

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  1. A. M. Deakin
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  2. A. N. Payne
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  3. G. J. Blackwell
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Deakin, A.M., Payne, A.N. & Blackwell, G.J. Role of potassium channels in the regulation of cytokine release from THP-1 cells. Agents and Actions 41 (Suppl 2), C188–C190 (1994). https://doi.org/10.1007/BF01987632

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  • DOI: https://doi.org/10.1007/BF01987632

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