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Modification of hepatotoxic effects of aflatoxin B1 in rabbits by immunization

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Summary

Reduction of acute toxic effect of aflatoxin B1 was achieved by immunizing the rabbits with small amounts of bovine serum albumin-aflatoxin B1 conjugate. Rabbits after immunization showed lower mortality, near normal serum isocitric dehydrogenase activity, no abnormality in livers when challenged with a single dose of aflatoxin B1. The results suggest that immunization might be used prophylactically against aflatoxicosis.

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References

  1. L. A. Goldblatt, Aflatoxin—Scientific background, control and implications. Academic Press, New York 1969.

    Google Scholar 

  2. G. N. Wogan, A. Rev. Pharmac.15, 437 (1975).

    Article  CAS  Google Scholar 

  3. F. S. Chu, M. T. Stephen Hsia and Piera Sun, J. Ass. off. analyt. Chem.60, 791 (1977).

    CAS  Google Scholar 

  4. J. J. Langone and H. Van Vunakis, J. natl. Cancer Inst.56, 591 (1976).

    Article  CAS  PubMed  Google Scholar 

  5. F. S. Chu and I. Ueno, Appl. environ. Microbiol.33, 1125 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. F. S. Chu, Fred C. C. Chang and R. D. Hinsdill, Appl. environ. Microbiol.31, 831 (1976).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. E. Bernt and H. U. Bergmeyer, in: Methods of enzymatic analysis, p. 624. Ed. H. U. Bergmeyer. Academic Press, New York; and Sigma technical bulletin number 175/150.

  8. R. M. Peck and E. B. Peck, Cancer Res.31, 1550 (1971).

    CAS  PubMed  Google Scholar 

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Author information

Author notes

  1. I. Ueno (Visiting scientist)

    Present address: University of Tokyo, Tokyo, Japan

Authors and Affiliations

  1. Food Research Institute and Department of Food Microbiology and Toxicology, University of Wisconsin, 53706, Madison, Wisconsin, USA

    I. Ueno (Visiting scientist) & F. S. Chu

Authors
  1. I. Ueno
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  2. F. S. Chu
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Additional information

Supported by the College of Agricultural and Life Sciences, the University of Wisconsin, by Public Health Service research grant number CA 15064 from the National Cancer Institute, and by contribution from food industries to the Food Research Institute of University of Wisconsin.

The authors wish to thank Prof. R. D. Hinsdill for his comments during the preparation of the manuscript.

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Ueno, I., Chu, F.S. Modification of hepatotoxic effects of aflatoxin B1 in rabbits by immunization. Experientia 34, 85–86 (1978). https://doi.org/10.1007/BF01921918

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