Summary
The effects of synthetic human gastric I (SHG I) and gastrin-like pentapeptide (PG) on jejunal water, electrolyte, and glucose absorption were studied in 11 normal subjects. The i.v. administration of graded doses of SHG I increased plasma gastrin levels similar to those after food intake and in the Zollinger-Ellison syndrome. SHG I and PG caused no significant changes in the net movement of water and solute. The findings indicate that gastrin has no direct effect on intestinal absorption in normal man, and does not account for the mechanism of diarrhea in the Zollinger-Ellison syndrome.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bennet A, Misiewicz JJ (1967) Gastroenterology 53:680
Bennet A, Misiewicz JJ, Waller SL (1967) Gut 8:470
Charters AC, Davidson WD, Odell WD, Thompson JC (1969) Gastroenterology 57:156
Cooper H, Levitan R, Fordtran JS, Ingelfinger FJ (1966) Gastroenterology 50:1
Davidson WD, Urushibara O, Thompson JC (1969) Proc Soc Exp Biol (NY) 129:711
Davidson WD, Urushibara O, Thompson JC (1969) Proc Soc Exp Biol (NY) 130:204
Donaldson RM Jr, vom Eigen PR, Dwight RW (1957) New Engl J Med 257:965
Ewe K, Laubental G, Hoditz U (1973) 79. Tg Dtsch Ges Inn Med, Wiesbaden (Abstr 190)
Gingell JC, Davies MW, Shields R (1968) Gut 9:111
Go VLW, Poley JR, Hofmann AF, Summerskill HJ (1970) Gastroenterology 58:639
Hubel KA (1972) Proc Soc Exp Biol (NY) 140:670
Logan CHJ, Connell AM (1966) Lancet I:996
Mansbach CM, Wilkins RM, Robbins WO, Tyor MP (1968) Arch Int Med 121:487
Mekhjian HS, Phillips SF, Hofmann AF (1969) Clin Res 17:307
Modigliani R, Mary JY, Bernier JJ (1973) Digestion 8:208
Modigliani R, Mary JY, De Peyer R, Bernier JJ (1974) 8th Ann Meet Eur Soc Clin Invest, Rotterdam, April 25–27 (Abstr 56)
Moshal MG, Broitman SA, Zamcheck N (1969) Clin Res 17:308
Raptis S, Rothenbuchner G, Schröder KE, Straub K, Birk J, Pfeiffer EF (1971) Acta Endocrinol (Copenh) [Suppl] 152:10
Shafer WH (1964) Ann Int Med 61:539
Smith AN, Hogg D (1966) Lancet I:403
Werner W, Rey HJ, Wielinger H (1970) Fresenius Z Anal Chem 252:224
Wright HK, Kabemba J, Herskovic T (1968) Surg Forum 19:282
Wright HK, Hersh T, Floch MH, Weinstein LD (1970) Am J Surg 119:250
Zollinger RM Personal communication
Author information
Authors and Affiliations
Additional information
Supported by the Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg, FRG (grant no. Do 175/1)
In memory of our late co-author Prof. Dr. K. Rommel
Rights and permissions
About this article
Cite this article
Dollinger, H.C., Raptis, S., Rommel, K. et al. Synthetic human gastrin I and gastrin-like pentapeptide in studies of intestinal absorption in man. Res. Exp. Med. 180, 223–228 (1982). https://doi.org/10.1007/BF01852294
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01852294