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Biochemical study of cyst fluid in human breast cystic disease: a review

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Summary

Gross cystic disease of the breast may sometimes indicate an increased risk of breast cancer. Biochemical analysis of the cyst fluid could suggest which cysts are associated with breast cancer risk, as well as providing insights into the pathophysiology of this condition. The Na+/K+ ratio appears to be associated with the histological classification of the cyst. Sulfoconjugated estrogens and androgens, especially DHEA-S, are often found at high levels. A number of gross cystic disease fluid proteins (GCDFPs) have been described, and several polypeptide growth factors including EGF and IGF-I are frequently found. It is hoped that biochemical analysis of these components of breast cyst fluids will shed further light on the role of gross cysts in relation to breast cancer.

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Authors and Affiliations

  1. Laboratorio de Análisis Clínicos, Córdoba 2077, 1120, Buenos Aires

    Carlos L. Enriori, María del C. Cremona & Pablo J. Enriori

  2. Servicio de Ginecología y Mastología del Hospital Francés, Buenos Aires

    Jorge E. Novelli

  3. Servicio de Cirugía del Hospital Cosme Argerich, Buenos Aires, Argentina

    René J. P. Hirsig

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  1. Carlos L. Enriori
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Enriori, C.L., Novelli, J.E., Cremona, M.d.C. et al. Biochemical study of cyst fluid in human breast cystic disease: a review. Breast Cancer Res Tr 24, 1–9 (1992). https://doi.org/10.1007/BF01832352

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