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Reversible cardiomyopathy in a child with Addison's disease

  • Neonatal and Pediatric Intensive Care
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Abstract

An 11-year-old boy in acute adrenal crisis was subsequently diagnosed with Addison's disease and presumably had an unrecognized preceding chronic adrenal insufficiency. His adrenal insufficiency and hypovolemic shock were promptly diagnosed and treated in the emergency room. However, 24 h later, signs of congestive heart failure developed and an echocardiogram revealed cardiomyopathy. He responded to i.v. dopamine and his cardiomyopathy resolved over some days. Acute adrenal insufficiency and actual ventricular dysfunction had not been described in humans until last year; this is the second reported case of cardiomyopathy in a patient with acute adrenal insufficiency.

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References

  1. Orth DN, Kovacs WJ, DeBold CR (1992) The adrenal cortex. In: Wilson JD, Foster DW (eds) Williams textbook of endocrinology, Saunders, Philadelphia, pp 489–619

    Google Scholar 

  2. Claussen MS, Landercasper J, Cogbill TH (1992) Acute adrenal insufficiency presenting as shock after trauma and surgery: three cases and review of the literature. J Trauma 32: 94–100

    Google Scholar 

  3. Dorin RI, Kearns PJ (1988) High output circulatory failure in acute adrenal insufficiency. Crit Care Med 16: 296–297

    Google Scholar 

  4. Lawton JM (1992) Acute adrenal insufficiency: hemodynamic and echocardiographic characteristics. Wis Med J 91: 214–216

    Google Scholar 

  5. Bouachour G, Tirot P, Gouello JP, Harry P, Alquier Ph (1994) Hemodynamic changes in acute adrenal insufficiency Intensive Care Med 20: 138–141

    Google Scholar 

  6. Piza J, Troper L, Cespedes R, Miller JH, Berenson GS (1971) Myocardial lesions and heart failure in infantile malnutrition. Am J Trop Med Hyg 20: 343–355

    Google Scholar 

  7. Wharton BA, Howells GR, McCance RA (1967) Cardiac failure in kwashiorkor. Lancet 2: 384–387

    Google Scholar 

  8. Weinsier RL, Krumdieck CL (1981) Death resulting from overzealous total parenteral nutrition: the refeeding syndrome revisited. Am J Clin Nutr 34: 393–399

    Google Scholar 

  9. Rogé CL, Silverman NH, Hart PA, Ray RM (1978) Cardiac structure growth pattern determined by echocardiography. Circulation 57: 285–290

    Google Scholar 

  10. Colan SD, Borow KM, Neumann A (1984) Lett ventricular end-systolic wall stress-velocity of fiber shortening relation: a load-independent index of myocardial contractility. J Am Coll Cardiol 4: 715–724

    Google Scholar 

  11. Cleghorn RA (1983) Cardiovascular failure in experimental adrenal insufficiency: a historical revival. Perspect Biol Med 27: 135–153

    Google Scholar 

  12. Narayan N (1983) Effects of adrenalectomy and in vivo administration of dexamethasone on ATP-dependent calcium accumulation by sarcoplasmic reticulum from rat heart. J Mol Cell Cardiol 15: 7–15

    Google Scholar 

  13. Narayan N, Khandelwal RL (1985) Microsomal phosphorylase in rat heart: depletion following adrenalectomy and restoration by in vivo administration of dexamethasone. Endocrinology 117: 1544–1549

    Google Scholar 

  14. Walker C, Butt W (1988) A case of cardiovascular collapse due to adrenal insufficiency. Aust Paediatr J 24: 197–198

    Google Scholar 

  15. Boston BA, DeGroff C, Hanna CE, Reller M (1994) Reversible cardiomyopathy in an infant with unrecognized congenital adrenal hyperplasia. J Pediatr 124: 936–938

    Google Scholar 

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Derish, M., Eckert, K. & Chin, C. Reversible cardiomyopathy in a child with Addison's disease. Intensive Care Med 22, 460–463 (1996). https://doi.org/10.1007/BF01712167

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  • DOI: https://doi.org/10.1007/BF01712167

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