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Clinical correlates of brainstem dysfunction in autistic children

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Abstract

Children with the diagnosis of autism were tested for brainstem auditory evoked potentials (BAEP), and information was gathered on their medical and developmental histories and current developmental levels of symptomatology. On comparing the nine autistic children having abnormal BAEPs and the seven autistic children with normal BAEPs, the former were found to have exhibited greater pathology in the areas of attention and social accessibility. No differences were found between the groups on measures of language, motor, or perceptual functioning, or on previous diagnoses or medical history. It is suggested that social and attentional pathology may be more specifically associated with the brainstem pathology that may characterize autism than are symptoms in other developmental areas.

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References

  • Achenbach, T. The Child Behavior Profile: I. Boys aged 6–11.Journal of Consulting and Clinical Psychology, 1978,46, 478–488.

    PubMed  Google Scholar 

  • Chiappa, K., & Norwood, A. Brainstem auditory evoked responses in clinical neurology: Utility and neuropathological correlates.Electroencephalography and Clinical Neurophysiology, 1977,43, 518.

    Google Scholar 

  • Connor, K. Connor's Parent Scales.Psychopharmacology Bulletin, special supplement, 1973.

  • DeMyer, M., Churchill, D., Pontius, M., & Gilkey, K. A comparison of five diagnostic systems for childhood schizophrenia and infantile autism.Journal of Autism and Childhood Schizophrenia, 1971,1, 175–189.

    PubMed  Google Scholar 

  • Doll, E.Vineland Social Maturity Scale Manual. Minneapolis: Educational Test Bureau, 1965.

    Google Scholar 

  • Hauser, S., DeLong, G., & Rosman N. Pneumographic findings in the infantile autism syndrome.Brain, 1975,98, 667–688.

    PubMed  Google Scholar 

  • Hecox, K., & Galambos, R. Brain stem auditory evoked responses in human infants and adults.Archives of Otolaryngology, 1974,99, 30–33.

    PubMed  Google Scholar 

  • Hutt, C., Hutt, S., Lee, D., & Ounsted, C. Arousal and childhood autism.Nature, 1964,204, 908.

    PubMed  Google Scholar 

  • Jewett, D., Romano, M., & Williston, J. Human auditory evoked potentials: Possible brainstem components detected on the scalp.Science, 1970,167, 1517–1578.

    PubMed  Google Scholar 

  • Jewett, D., & Williston, J. Auditory-evoked far fields averaged from the scalp of humans.Brain, 1971,94, 681–696.

    PubMed  Google Scholar 

  • Krug, D., Arick, J., & Almond, P. Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior.Journal of Child Psychology and Psychiatry, in press.

  • Leech, R., & Alvord, E. Anoxic-ischemic encephalopathy in the human neonatal period.Archives of Neurology, 1977,34, 109–113.

    PubMed  Google Scholar 

  • Lobascher, M., Kingerlee, P., & Gubbay, S. Childhood autism: An investigation of etiological factors in twenty-five cases.British Journal of Psychiatry, 1970,117, 525–529.

    PubMed  Google Scholar 

  • MacCulloch, M., & Williams, C. On the nature of infantile autism.Acta Psychiatrica Scandinavica, 1971,47, 295–314.

    PubMed  Google Scholar 

  • McGinn, J.Four Language Assessment Scales. Boston: League School, Government Center, 1979.

    Google Scholar 

  • Ornitz, E. Vestibular dysfunction in schizophrenia and childhood autism.Comprehensive Psychiatry, 1970,11, 159–173.

    PubMed  Google Scholar 

  • Ornitz, E., Guthrie, D., & Farley, A. The early symptoms of childhood autism. In G. Serban (Ed.),Cognitive defects in the development of mental illness, New York: Brunner/Mazel, 1978.

    Google Scholar 

  • Ornitz, E., & Ritvo, E. Medical assessment. In E. Ritvo (Ed.),Autism: Diagnosis, current research and management. New York: Spectrum, 1976.

    Google Scholar 

  • Picton, T., & Hillyard, S. Human auditory evoked potentials. II. Effects of attention.Electroenphalography and Clinical Neurophysiology, 1974,36, 191–200.

    Google Scholar 

  • Picton, T., Hillyard, S., Galambos, R., & Schiff, M. Human auditory attention: A central or peripheral process?Science, 1971,171, 351–353.

    Google Scholar 

  • Rimland, B.Infantile autism. New York: Appleton-Century-Crofts, 1964.

    Google Scholar 

  • Rimland, B. The differentiation of childhood psychoses.Journal of Autism and Childhood Schizophrenia, 1971,1, 161–174.

    PubMed  Google Scholar 

  • Robinson, K., & Rudge, P. Abnormalities of the auditory evoked potentials in patients with multiple sclerosis.Brain, 1977,100, 19–40.

    PubMed  Google Scholar 

  • Rutter, M. Concepts of autism: A review of research.Journal of Child Psychology and Psychiatry, 1968,9, 1–25.

    PubMed  Google Scholar 

  • Salamy, A., & McKean, C. Postnatal development of human brainstem potentials during the first year of life.Electroencephalography and Clinical Neurophysiology, 1976,40, 418–426.

    PubMed  Google Scholar 

  • Schopler, E., Reichler, R. J., DeVellis, R. F., & Daly, K. Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS).Journal of Autism and Developmental Disorders, 1980,10, 91–103.

    PubMed  Google Scholar 

  • Simon, N. Echolalic speech in childhood autism. Consideration of possible underlying loci of brain damage.Archives of General Psychiatry, 1975,32, 1439–1448.

    PubMed  Google Scholar 

  • Skoff, B., Mirsky, A., & Turner, D. Prolonged brainstem transmission time in autismPsychiatry Research, 1980,2, 157–166.

    PubMed  Google Scholar 

  • Starr, A., & Achor, J. Auditory brain stem responses in neurological disease.Archives of Neurology, 1975,32, 761–768.

    PubMed  Google Scholar 

  • Starr, A., & Achor, J. Anatomical and physiological origins of auditory brain stem responses (ARB). In D. Lehmann & E. Callaway (Eds.),Human evoked potentials: Applications and problems. New York: Plenum Press, 1979.

    Google Scholar 

  • Starr, A., & Hamilton, A. Correlation between confirmed sites of neurological lesions and abnormalities of far field auditory brainstem responses.Electroencephalography and Clinical Neurophysiology, 1976,41, 595–608.

    PubMed  Google Scholar 

  • Stockard, J., Stockard, J., & Sharbrough, F. Detection and localization of occult lesions with brainstem auditory responses.Mayo Clinic Proceedings, 1977,52, 261–269.

    Google Scholar 

  • Stockard, J., Stockard, J., & Sharbrough, F. Nonpathologic factors influencing brainstem auditory evoked potentials.American Journal of EEG Technology, 1978,18, 177–209.

    Google Scholar 

  • Student, M., & Sohmer, H. Evidence from auditory nerve and brainstem evoked responses for an organic brain lesion in children with autistic traits.Journal of Autism and Childhood Schizophrenia, 1978,8, 13–20.

    PubMed  Google Scholar 

  • Student, M., & Sohmer, H. Erratum.Journal of Autism and Developmental Disorder, 1979,9, 309.

    Google Scholar 

  • Windle, W., Becker, R., & Weil, A. Alterations in brain structure after asphyxiation at birth.Journal of Neuropathology and Experimental Neurology, 1944,3, 224–238.

    Google Scholar 

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This work was supported in part by the following grants: NS-12201 from NINCDS-NIH, K3-14,915 from NIMH-ADAMHA (Research Scientist Award to A. F. Mirsky), MHOO250 from NIMH-ADAMHA (Research Scientist Development Award to D. Fein), MH-15189 (NIMH, Research Training Grant to B. Skoff), and UHGRS-561 from University Hospital. We wish to thank Dr. Fred Krell, Joseph Piette, and the staff and students at the May Institute, Chatham, Massachusetts.

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Fein, D., Skoff, B. & Mirsky, A.F. Clinical correlates of brainstem dysfunction in autistic children. J Autism Dev Disord 11, 303–315 (1981). https://doi.org/10.1007/BF01531513

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