Abstract
To determine if malabsorption of zinc contributes to the zinc deficiency found in cirrhosis, the absorption of an oral dose of ZnCl2, labeled with65Zn and a nonabsorbed marker51CrCl3, was determined from the ratio of these isotopes in a stool specimen. Average65Zn absorption in 25 alcoholic cirrhotics, 37±17% (sd), was low compared to 55±16% in 31 healthy volunteer controls (P<0.01). In contrast, mean65Zn absorption, 47±11%, in 11 nonalcoholic cirrhotics was not significantly different from the average result in healthy controls. Low65Zn absorption was accompanied by low leukocyte zinc in a subgroup of alcoholic cirrhotics with ascites and/or ascites and encephalopathy, but not in the subgroup in which these clinical features were absent. Thus, low zinc absorption contributes to zinc deficiency in decompensated alcoholic cirrhosis. The failure to find similar abnormalities in nonalcoholic cirrhosis suggests that the long-standing consumption of alcoholic beverages contributes to the malabsorption of zinc.
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McClain CJ, Su L: Zinc deficiency in the alcoholic: A review. Alcoholism 7:5–10, 1983
Vallee BL, Wacker WEC, Bartholomay AF, Hoch FL: Zinc metabolism in hepatic dysfunction. II. Correlation of metabolic patterns with biochemical findings. N Engl J Med 257:1055–1065, 1957
Fredericks RE, Tanaka KR, Valentine WN: Zinc in human blood cells: Normal values and abnormalities associated with liver disease. J Clin Invest 39:1651–1656, 1960
Sullivan J, Lankford HG: Urinary excretion of zinc in alcoholism and post-alcoholic cirrhosis. Am J Clin Nutr 10:153–157, 1962
Prasad AS, Oberleas D, Halsted JA: Determination of zinc in biological fluids by atomic absorption spectrophotometry in normal and cirrhotic patients. J Lab Clin Med 66:508–516, 1965
Keeling PWN, Jones RB, Hilton PJ, Thompson RPH: Reduced leukocyte zinc in liver disease. Gut 21:561–564, 1980
Walker BE, Dawson JB, Kelleher J, Losowsky MS: Plasma and urinary zinc in patients with malabsorption syndromes or hepatic cirrhosis. Gut 14:943–948, 1973
McClain CJ, Van Thiel DH, Parker S, Badzin LK, Gilbert H: Alterations in zinc, vitamin A, and retinol-binding protein in chronic alcoholics: A possible mechanism for night blindness and hypogonadism. Alcoholism 3:135–141, 1979
Sullivan JF, Jetton MM, Burch RE: A zinc tolerance test. J Lab Clin Med 93:485–492, 1979
Milman N, Hvid-Jacobsen K, Hegnhoj J, Sorensen SS: Zinc absorption in patients with compensated alcoholic cirrhosis. Scand J Gastroenterol 18:871–875, 1983
Mills PR, Fell GS, Bessent RG, Nelson LM, Russel RI: A study of zinc metabolism in alcoholic cirrhosis. Clin Sci 64:527–535, 1983
Kiilerich S, Dietrichson O, Loud FB, Naestoft J, Christoffersen P, Juhl E, Kjems G, Christiansen C: Zinc depletion in alcoholic liver diseases. Scand J Gastroenterol 15:363–367, 1980
Baker JP, Detsky AS, Wesson DE, Wolman SL, Stewart S, Whitewell J, Langer B, Jeejeebhoy KN: A comparison of clinical judgement and objective measurements. N Engl J Med 306:969–972, 1982
Morgan MY: Alcohol and nutrition. Br Med Bull 38:21–29, 1982
Payton KB, Flanagan PR, Stinson EA, Chodirker DP, Chamberlain MJ, Valberg LS: Technique for the determination of human zinc absorption from measurement of radioactivity in a fecal sample or the body. Gastroenterology 83:1264–1270, 1982
McLellan JF, Mamacos JP, Jones C, Valberg LS, Chamberlain M: A versatile counter for large volume samples. Int J Appl Radiat Isot 30:233–235, 1979
Whitehouse RC, Prasad AS, Rabbani PI, Cossack ZT: Zinc in plasma, neutrophils, lymphocytes and erythrocytes as determined by flameless atomic absorption spectrophotometry. Clin Chem 28:475–480, 1982
Sullivan JF, Williams RV, Burch RE: The metabolism of zinc and selenium in cirrhotic patients during six weeks of zinc ingestion. Alcoholism 3:235–239, 1979
Ilchyshyn A, Mendelsohn S: Zinc deficiency due to alcoholic cirrhosis mimicking acrodermatitis enteropathica. Br Med J 284:1676, 1982
Morrison SA, Russell RM, Carney EA, Oaks EV: Zinc deficiency: A cause of abnormal dark adaptation in cirrhotics. Am J Clin Nutr 31:276–281, 1978
Keeling PWN, O'Day J, Ruse W, Thompson RPH: Zinc deficiency and photoreceptor dysfunction in chronic liver disease. Clin Sci 62:109–111, 1982
Scholmerich J, Lohle E, Kottgen E, Gerok W: Zinc and vitamin A deficiency in liver cirrhosis. Hepatogastroenterology 30:119–125, 1983
Dinsmore WW, Callender ME, McMaster D, Todd SJ, Love AHG: Zinc absorption in alcoholics using zinc 65.In Trace Elements in Man and Animals-5. CF Mills, I Bremner, JK Chesters, PJ Aggett (eds). UK, Commonwealth Agricultural Bureau Publications, 1985 (in press).
Prasad AS, Rabbani P, Abbasii A, Bowersox E, Spivey Fox MR: Experimental Zinc Deficiency in Humans. Ann Intern Med 89:483–490, 1978
Jones RB, Keeling PWN, Hilton PJ, Thomson RPH: The relationship between leukocyte and muscle zinc in health and disease. Clin Sci 60:237–239, 1981
Keeling PWN, Ruse W, Bull J, Hannigan B, Thompson RPH: Direct measurement of the hepatointestinal extraction of zinc in cirrhosis and hepatitis. Clin Sci 61:441–444, 1981
Wilson FA, Hoyumpa AM: Ethanol and small intestinal transport. Gastroenterology 76:388–403, 1979
Hill CH: The effect of alcohols on absorption and tissue uptake of trace metals. Fed Proc Fed Am Soc Exp Biol 28:300, 1969
Antonson DL, Vanderhoof JA: Effect of chronic ethanol ingestion on zinc absorption in rat small intestine. Dig Dis Sci 28:604–608, 1983
Sullivan JF, Lankford HG: Zinc metabolism and chronic alcoholism. Am J Clin Nutr 17:57–63, 1965
Flanagan PR, Cluett J, Chamberlain MJ, Valberg LS: Dual isotope method for determination of human zinc absorption: The use of a test meal of turkey meat. J Nutr 115:111–122, 1985
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Valberg, L.S., Flanagan, P.R., Ghent, C.N. et al. Zinc absorption and leukocyte zinc in alcoholic and nonalcoholic cirrhosis. Digest Dis Sci 30, 329–333 (1985). https://doi.org/10.1007/BF01403841
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DOI: https://doi.org/10.1007/BF01403841