Summary
The influence of tumor-necrosis-factor-α (TNF-α), granulocytemacrophage colony-stimulating factor (GM-CSF), interleukine-1 (IL-1) and IL-3 on the in vitro reactivation frequency and replication rate of trigeminal ganglia of mice latently infected with herpes simplex virus (HSV) strain KOS was studied. It could be demonstrated that TNF-α and possibility GM-CSF, but not IL-1 and IL-3, enhanced the reactivation frequency and replication of HSV. Interferon α/β (IFNα/β) prevented reactivation and replication.
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Walev, I., Podlech, J. & Falke, D. Enhancement by TNF-α of reactivation and replication of latent herpes simplex virus from trigeminal ganglia of mice. Archives of Virology 140, 987–992 (1995). https://doi.org/10.1007/BF01315409
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DOI: https://doi.org/10.1007/BF01315409