Abstract
Massive secretory diarrhea is associated with some villous adenomas. The mechanism of this secretion is unknown but the character of the diarrhea resembles that of cyclic nucleotide-mediated diarrheas. We have compared the cyclic nucleotide metabolism of a large secretory villous adenoma with a nonsecretory villous adenoma, a solid, carcinoma and their normal mucosae. The adenylate cyclase, cyclic AMP content, and a cyclic AMP-dependent protein kinase ratios in the secretory tumor were increased as compared to these values in the nonsecretory tumors and normal mucosae, a situation similar to that seen with cholera toxin-induced diarrhea. Our data suggest that the massive diarrhea in our patient with a secretory villous adenoma may be related to increased adenylate cyclase activity.
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This work was supported in part by NIH grant AM-22036 (Dr. Schlondorff).
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Jacob, H., Schlondorff, D., Onge, G.S. et al. Villous adenoma depletion syndrome. Digest Dis Sci 30, 637–641 (1985). https://doi.org/10.1007/BF01308412
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DOI: https://doi.org/10.1007/BF01308412