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Malignant lymphoma of the liver

Report of five cases and review of the literature

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Abstract

Primary hepatic lymphoma is a rare disease. We report five cases here and summarize clinical and pathologic features of our own and reported cases from Western countries and Japan. The total number of cases was 68. The age of patients ranged from 7 to 87 years (median 55) with a male-to-female ratio of 3.1:1. Chronic hepatitis or cirrhosis before onset of hepatic lymphoma was noted in 44% of Japanese cases and 9.6% of Western cases. Macroscopically, the liver was occupied by solitary mass (60%), multiple masses (35%), or a diffuse lesion without nodule formation (5%). Histologically all cases were non-Hodgkin's lymphoma with the diffuse large cell type being most common. Three cases (4.4%) were follicular lymphoma. Immunohistochemically about 80% of the cases were B-cell type. Follow-up study showed that hepatic lymphoma had a relatively favorable prognosis when early detection of the disease was possible.

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References

  1. Freeman C, Berg JW, Cutler SJ: Occurrence and prognosis of extranodal lymphomas. Cancer 29:252–260, 1972

    Google Scholar 

  2. Aozasa K, Tsujimoto M, Sakurai M, Honda M, Yamashita K, Hanada M, Sugimoto A: Non-Hodgkin's lymphomas in Osaka, Japan. Eur J Cancer Clin Oncol 21:487–492, 1985

    Google Scholar 

  3. Aozasa K, Inoue A, Tajima K, Miyauchi A, Matsuzuka F, Kuma K: Malignant lymphomas of the thyroid gland. Analysis of 79 patients with emphasis on histologic prognostic factors. Cancer 58:100–104, 1986

    Google Scholar 

  4. Maeda H, Sasaki R, Kimoto H, Yamashita K, Matsunaga T, Aozasa K: Intermediate lymphocytic lymphoma of the salivary gland. Cancer 62:203–205, 1988

    Google Scholar 

  5. Iuchi K, Aozasa K, Yamamoto S, Mori T, Tajima K, Minato K, Mukai K, Komatsu H, Takagi H, Kobashi Y, Yamabe H, and Shimoyama M: Non-Hodgkin's lymphoma of the pleural cavity developing from long-standing pyo horax. Summary of clinical and pathological findings in thirty-seven cases. Jpn J Clin Oncol 19:249–257, 1989

    Google Scholar 

  6. Sutton E, Malatjalian P, Hayne OA, Hanly IG: Liver lymphoma in systemic lupus erythematousus. J Rheumatol 16:1584–1588, 1989

    Google Scholar 

  7. Lisker-Melman M, Pittaluga S, Pluda JM, Kleiner DE, Thompson P, Martin P, Yarchoan R, DiBisceglie AM: Primary lymphoma of the liver in a patient with acquired immune deficiency syndrome and chronic hepatitis B. Am J Gastroenterol 84:1445–1448, 1989

    Google Scholar 

  8. Caccmo D, Pervez NK, Marchevsky A: Primary lymphoma of the liver in the acquired immunodeficiency syndrome. Arch Pathol Lab Med 110:553–555, 1986

    Google Scholar 

  9. Scoazec J-Y, Degott C, Brousse N, Barge J, Molas G, Potet F, Benhamou J-P: Non-Hodgkin's lymphoma presenting as a primary tumor of the liyer: Presentation, diagnosis and outcome in eight patients. Hepatology 13:870–875, 1991

    Google Scholar 

  10. Honda H, Franken EA, Barloon TJ, Smith JL: Hepatic lymphoma in cyclosporine-treated transplant recipients: Sonographic and CT findings. Am J Roentgenol 152:501–503, 1989

    Google Scholar 

  11. Sou T, Takahara T, Nishizono K, Hashimoto S, Yoshinaka H, Watanabe N, Isaka H: A case of primary reticulum cell sarcoma of the liver. Jpn J Clin Exp Med 53:2411–2414, 1976

    Google Scholar 

  12. Talamo ST, Dekker A, Gurechki J, Sigh G: Primary hepatic malignant lymphoma: Its occurrence in a patient with chronic active hepatitis, cirrhosis, and hepatocellular carcinoma associated with hepatitis B viral infection. Cancer 46:336–339, 1980

    Google Scholar 

  13. Sonoyama K, Tsuchiya S, Yoshida H, Imaoka Y, Kishimoto Y, Horie H, Shubou H: A case of primary hepatic lymphoma detected by laparoscopy. Acta Hepatol Jpn 23:1237, 1982 (in Japanese)

    Google Scholar 

  14. Namba K, Sasaki N, Hino T, Kimura N, Ohta N, Hiramoto T: Liver disease and malignant lymphoma. J Hiroshima Med Assoc 37:140–142, 1984 (in Japanese)

    Google Scholar 

  15. Horikoshi N, Inagaki J, Inoue T, Okada Y, nakada H, Ogawa I, Sugano J, Takano Y: An autopsy case of primary hepatic malignant lymphoma. Jpn J Soc Res 24:86, 1984 (in Japanese)

    Google Scholar 

  16. Alami SY, Bowman RO, Reese MH, Race GJ: Extranodal lymphosarcoma of the left liver lobe with paraproteinemia. Arch Intern Med 123:64–68, 1969

    Google Scholar 

  17. Torres A: Primary lymphocytic follicular lymphoma of liver. Cancer 23:1185–1189, 1969

    Google Scholar 

  18. Torres A, Bollozos GD: Primary reticulum cell sarcoma of liver. Cancer 27:1489–1492, 1971

    Google Scholar 

  19. Chambers TJ, O'Donoghue DP, Stansfeld AG: A case of primary lymphoma of the liver. J Clin Pathol 29:967–970, 1976

    Google Scholar 

  20. Strayer DS, Reppuun TS, Levin M, Deschryver-Kecskemeti K: Primary lymphoma of the liver. Gastroenterology 78:1571–1576, 1980

    Google Scholar 

  21. Leavy MF, Ibrahim EM, Worth AJ: Primary hepatic lymphoma: Two cases reports and review of the literature. Med Pediatr Oncol 10:575–581, 1982

    Google Scholar 

  22. Miller ST, Wollner N, Neyers PA, Exelby P, Jereb B, Miller DR: Primary hepatic or hepatosplenic non-Hodgkin's lymphoma in children. Cancer 52:2285–2288, 1983

    Google Scholar 

  23. Daniel SJ, Attiyeh FF, Dire JJ, Pyun HJ, Carroll DS, Attia A: Primary lymphoma of the liver treated with extended left hepatic lobectomy. Cancer 55:206–209, 1985

    Google Scholar 

  24. Osbone MB, Butler JJ, Guarda LA: Primary lymphoma of the liver. Ten cases and a review of the literature. Cancer 56:2902–2910, 1985

    Google Scholar 

  25. DeMent SH, Mann RB, Staal SP, Kuhajda FP, Boitnott JK: Primary lymphomas of the liver. Am J Clin Pathol 88:255–263, 1987

    Google Scholar 

  26. Aghai E, Quitt M, Lurie M, Antal S, Cohen L, Bitterman H, Froom P: Primary hepatic lymphoma presenting as symptomatic immune thrombocytopenic purpura. Cancer 60:2308–2311, 1987

    Google Scholar 

  27. Ryan J, Straus DJ, Lange C, Fillipa DA, Botet JF, Sanders LM, Shiu MH, Fortner JG: Primary lymphoma of the liver. Cancer 61:370–375, 1988

    Google Scholar 

  28. Pescovits MD, Snover DC, Orchard P, Neglia JP, Najarian JS, Payne WD: Primary hepatic lymphoma in an adolescent treated with hepatic lobectomy and chemotherapy. Cancer 65:2222–2226, 1990

    Google Scholar 

  29. Andreola S, Audisio RA, Mozzaferro V, Doci R, Makowka L, Gennari L: Primary lymphoma of the liver showing immunohistochemical evidence of T-cell origin. Successful management of right trisegmentectomy. Dig Dis Sci 33:1632–1636, 1988

    Google Scholar 

  30. Suzuki H, Sakuma H, Morifuji T, Kasukawa R, Yanaginuma Y, Takahashi K: An autopsy case of primary plasmacytoid lymphosarcoma of liver. J Jpn Soc Intern Med 69:1531, 1980 (in Japanese)

    Google Scholar 

  31. Yamashita K, Tari A, Hino F, Hikarinami Y, Nakamura K: A case of primary hepatic lymphoma. Jpn J Gastroenterol 80:283, 1983 (in Japanese)

    Google Scholar 

  32. Ida M, Nishijima H, Takayama S: A case of primary hepatic lymphoma. Nippon-Choonpa-Gakkai 43:17–18, 1983 (in Japanese)

    Google Scholar 

  33. Itoh M, Ono T, Oseto T, Yamamoto K, Namba K, Itagaki T: A case of primary poorly differentiated lymphocytic lymphoma diagnosed by liver biopsy. Jpn J Gastroenterol 80:133, 1983 (in Japanese)

    Google Scholar 

  34. Kawamoto T, Ido K, Takahashi H: An autopsy case of primary hepatic malignant lymphoma. Jpn J Gastroenterol 82:173, 1985 (in Japanese)

    Google Scholar 

  35. Inoue J, Nakagawa M, Oobayashi N: A case of primary hepatic malignant lymphoma. Jpn J Gastroenterol 82:153, 1985 (in Japanese)

    Google Scholar 

  36. Imamine S, Ogawa Y, Nakanishi K, Onchi S, Horiike N, Nonaka T, Kondoh H, Doukyou K, Ymaguchi S, Kumamoto I, Ohkubo K, Nagai T, Satoh K, Miyaoka H, Sakagami H, Ohta Y: A case of hepatic lymphoma diagnosed by laparoscopy. Gastroenterol Endsc 31:522, 1989 (in Japanese)

    Google Scholar 

  37. The Non-Hodgkin's Lymphoma Pathologic Classification Project: National Cancer Institute sponsored study of classification of non-Hodgkin's lymphomas: Summary and description of a working formulation for clinical usage. Cancer 49:2112–2135, 1982

    Google Scholar 

  38. Takami T, Ishii Y, Yuasa H, Kikuchi K: Three distinct antigen systems on human B cell subpopulations as defined by monoclonal antibodies. J Immunol 134:828–834, 1985

    Google Scholar 

  39. Poppema S, Hollema H, Visser L, Vos H: Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with lymphocyte subsets in paraffin-embedded tissue sections. Am J Pathol 127:418–429, 1987

    Google Scholar 

  40. Norton AJ, Ramsay AD, Smith O, Beverly PCL, Issacson PG: Monoclonal antibody (UCHL-1) that recognizes normal and neoplastic T cells in routinely fixed tissues. J Clin Pathol 39:339–405, 1986

    Google Scholar 

  41. Delsol G, Al Saati T, Gatter KC, Gerdes J, Schwarting R, Caveriviere P, Rigal-Huget F, Robert A, Stein H, Mason DY: Coexpression of epithelial membrane antigen (EMA), Ki-1 and interleukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosis. Am J Pathol 130:59–70, 1988

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Nara Medical University, Shijo-cho, 634, Kashihara, Japan

    Masahiko Ohsawa,  Katsuyuki Aozasa, Keisuke Horiuchi, Makoto Kataoka, Jin-Ichi Hida, Hiroyuki Shimada, Kuniyuki Oka & Yasushi Wakata

  2. Second Department of Surgery, Nagoya City University Medical cchool, Nagoya, Japan

    Masahiko Ohsawa,  Katsuyuki Aozasa, Keisuke Horiuchi, Makoto Kataoka, Jin-Ichi Hida, Hiroyuki Shimada, Kuniyuki Oka & Yasushi Wakata

  3. First Department of Surgery, Kinki University School of Medicine, Osaka, Japan

    Masahiko Ohsawa,  Katsuyuki Aozasa, Keisuke Horiuchi, Makoto Kataoka, Jin-Ichi Hida, Hiroyuki Shimada, Kuniyuki Oka & Yasushi Wakata

  4. Department of Pathology, the Tokyo Metroporitan Geriatrics Hospital, Tokyo, Japan

    Masahiko Ohsawa,  Katsuyuki Aozasa, Keisuke Horiuchi, Makoto Kataoka, Jin-Ichi Hida, Hiroyuki Shimada, Kuniyuki Oka & Yasushi Wakata

  5. Department of Pathology, National Institute of Radiological Science, Chiba, Japan

    Masahiko Ohsawa,  Katsuyuki Aozasa, Keisuke Horiuchi, Makoto Kataoka, Jin-Ichi Hida, Hiroyuki Shimada, Kuniyuki Oka & Yasushi Wakata

  6. Department of Pathology, Kyoto Min-iren Institute of Pathology, Kyoto, Japan

    Masahiko Ohsawa,  Katsuyuki Aozasa, Keisuke Horiuchi, Makoto Kataoka, Jin-Ichi Hida, Hiroyuki Shimada, Kuniyuki Oka & Yasushi Wakata

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  1. Masahiko Ohsawa
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  2. Katsuyuki Aozasa
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  3. Keisuke Horiuchi
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  4. Makoto Kataoka
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  5. Jin-Ichi Hida
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  6. Hiroyuki Shimada
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  7. Kuniyuki Oka
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  8. Yasushi Wakata
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Additional information

This work is supported in part by a Grant-in-Aid for Cancer Research (1-1) and grants from the Ministry of Education, Science and Culture (02152103) and the Foundation for Promotion of Cancer Research, Japan.

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Ohsawa, M., Aozasa, K., Horiuchi, K. et al. Malignant lymphoma of the liver. Digest Dis Sci 37, 1105–1109 (1992). https://doi.org/10.1007/BF01300294

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  • DOI: https://doi.org/10.1007/BF01300294

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