Skip to main content
SpringerLink
Log in

Hepatocanalicular injury associated with vitamin A derivative etretinate

An idiosyncratic hypersensitivity reaction

  • Case Report
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Mayer H, Bollag W, Hanni R, Ruegg R: Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology. Experientia 34:1105–1119, 1978

    Google Scholar 

  2. Dickens CH: Retinoids: A review. J Am Acad Dermatol 11:541–552, 1984

    Google Scholar 

  3. Frederiksson T: Antipsoriatic activity of retinoic acid (vitamin A acid). Dermatologica 142:133–136, 1971

    Google Scholar 

  4. Jarrett A, Spearman R: Vitamin A and the skin. Br J Dermatol 82:197–199, 1970

    Google Scholar 

  5. Russell R, Boyer J, Baggheri S, Hruban Z: Hepatic injury from chronic hypervitaminosis A resulting in portal hypertension and ascites. N Engl J Med 291:435–461, 1974

    Google Scholar 

  6. Hruban Z, Russell R, Boyer J, Glagov S, Bagheri S: Ultrastructural changes in livers of two patients with hypervitaminosis A. Am J Pathol 76(3):451–461, 1974

    Google Scholar 

  7. Dahl B, Mollenbach K, Reymann F: Treatment of psoriasis vulgaris with a new retinoic acid derivative Ro 10-9359. Dermatologica 154:261–267, 1977

    Google Scholar 

  8. Fredriksson T: Oral treatment of psoriasis and pustulosis palmoplantaris with Ro 10-9359. Dermatologica 157(Suppl 1):13–18, 1978

    Google Scholar 

  9. Glazer S, Roenigk H, Yokoo H, Sparberg M: A study of potential hepatoxicity of etretinate used in the treatment of psoriasis. J Am Acad Dermatol 6:63–687, 1982

    Google Scholar 

  10. Glazer S, Roenigk H, Yokoo H, Sparberg M, Pravicini U: Ultrastructural survey and tissue analysis of human livers after a 6-month course of etretinate. J Am Acad Dermatol 10:632–638, 1984

    Google Scholar 

  11. Roenigk H, Gibstine C, Glazer S, Sparberg M, Yokoo H: Serial liver biopsies in psoriatic patients receiving long-term etretinate. Br J Dermatol 112:77–81, 1985

    Google Scholar 

  12. Orfanos C, Mahrle G, Goerz G, Happle R, Hofbauer M, Landes E, Schimpf A: Laboratory investigations in patients with generalized psoriasis under oral retinoid treatment. Dermatologica 159:62–70, 1979

    Google Scholar 

  13. Orfanos C, Bauer E: Evidence for anti-inflammatory activities of oral synthetic retinoids: Experimental findings and clinical experience. Br J Dermatol 109(Suppl 25):55–60, 1983

    Google Scholar 

  14. Fredriksson R, Pettersson U: Oral treatment of pustulosis palmoplantaris with a new retinoid: Ro 10-9359. Dermatologica 158:60–64, 1979

    Google Scholar 

  15. Thune P, Mork N: A case of centrolobular toxic necrosis of the liver due to aromatic retinoid—Tigason (Ro 10-9359). Dermatologica 160:405–408, 1980

    Google Scholar 

  16. Weiss V, Layden T, Spinowitz A, Buys C, Nemchausky B, West D, Emmons K: Chronic active hepatitis associated with etretinate therapy. Br J Dermatol 112:591–597, 1985

    Google Scholar 

  17. Foged E, Jacobsen F: Side effects due to Ro 10-9359. Dermatologica 164:395–403, 1982

    Google Scholar 

  18. van Voorst Vader P, Houthoff H, Effink H, Gips C: Etretinate (Tigason) hepatitis in 2 patients. Dermatologica 168:41–46, 1984

    Google Scholar 

  19. Gavish D, Katz M, Gottehrer N, Israeli A, Lijovetzky G, Holubar K: Cholestatic jaundice, an unusual side effect of etretinate. J Am Acad Dermatol 13(4):669–670, 1985

    Google Scholar 

  20. Weiss V, West D, Ackerman R, Robinson L: Hepatotoxic reactions in a patient treated with etretinate. Arch Dermatol 120:104–106, 1984

    Google Scholar 

  21. Zimmerman HJ: Hepatotoxicity. The Adverse Effects of Drugs and Other Chemicals on the Liver. Appleton-Century-Crofts, New York, 1978, pp 349–369

    Google Scholar 

  22. Ishak KG, Irey NS: Hepatic injury associated with phenothiazines: Clinicopathologic and follow-up study of 36 patients. Arch Pathol 93:283, 1972

    Google Scholar 

  23. Paravicini U, Stocket K, MacNamara PJ, Hanni R, Busslinger A: On metabolism and pharmacokinetics of an aromatic retinoid. Ann NY Acad Sci 359:54–67, 1981

    Google Scholar 

  24. Camuto P, Shupack J, Orbuch P, Tobias H, Sidhu G, Feiner H: Long-term effects of etretinate on the liver in psoriasis. Am J Surg Pathol 11(1):30–37, 1987

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gastrointestinal section of the Department of Medicine, Hospital of the University of Pennsylvania University of Pennsylvania, School of Medicine, 3 Dulles Building, 3400 Spruce Street, 19104, Philadelphia, Pennsylvania

    Margaret R. Khouri MD, Scott H. Saul MD, Andrzej A. Dlugosz MD &  Roger D. Soloway MD

  2. Section of Surgical Pathology of the Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania University of Pennsylvania, School of Medicine, 3 Dulles Building, 3400 Spruce Street, 19104, Philadelphia, Pennsylvania

    Margaret R. Khouri MD, Scott H. Saul MD, Andrzej A. Dlugosz MD &  Roger D. Soloway MD

  3. Department of Dermatology, Hospital of the University of Pennsylvania University of Pennsylvania, School of Medicine, 3 Dulles Building, 3400 Spruce Street, 19104, Philadelphia, Pennsylvania

    Margaret R. Khouri MD, Scott H. Saul MD, Andrzej A. Dlugosz MD &  Roger D. Soloway MD

Authors
  1. Margaret R. Khouri MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Scott H. Saul MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andrzej A. Dlugosz MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Roger D. Soloway MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Khouri, M.R., Saul, S.H., Dlugosz, A.A. et al. Hepatocanalicular injury associated with vitamin A derivative etretinate. Digest Dis Sci 32, 1207–1211 (1987). https://doi.org/10.1007/BF01300208

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01300208

Key Words

Search

Navigation