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Spontaneous mutation of cowpox-virus by means of eggpassage

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Summary

The present paper reports the occurrence of a spontaneous mutation of cowpox virus by serial egg passage. By comparing the mutant and the parent strain evidence is obtained of mutation effects upon the biological activity of the cowpox strain. The tentative suggestion to denominate this mutant “cowpox-vaccinia” is based on the gross and microscopic lesions of the chorio-allantoic membrane of the chick embryo and the difference in reaction in monkeys, calves and other experimental animals to variolavaccinia.

Preliminary experiments suggest that cowpox-vaccinia can be applied to immunize cattle against genuine cowpox and perhaps man against smallpox.

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Authors and Affiliations

  1. Department of bacteriology and experimental pathology of the Institute for Preventive Medicine, Leiden, Holland

    H. A. E. van Tongeren

Authors
  1. H. A. E. van Tongeren
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Additional information

Aided by a grant of the National Health Research Council T. N. O.

Grateful acknowledgement for general assistance is due to MissO. J. A. Calmeyer, MissN.Filippo (histology) and MrC.Snieder (photography).

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van Tongeren, H.A.E. Spontaneous mutation of cowpox-virus by means of eggpassage. Archiv f Virusforschung 5, 35–52 (1952). https://doi.org/10.1007/BF01245138

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  • DOI: https://doi.org/10.1007/BF01245138

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