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Pharmacokinetics of ethanol after oral administration in the fasting state

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Abstract

A nonlinear relationship between the total area under the blood ethanol concentration-time curve and the orally administered dose (mg/kg) of ethanol was observed in fasting subjects. A preliminary model, based on physiological considerations, was elaborated and shown, for the first time, to describe the entire time course of blood alcohol concentrations after four different doses of alcohol. The model could be refined by further experimentation.

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Author notes

  1. Allen J. Sedman

    Present address: School of Medicine, Washington University, St. Louis, 63110, Missouri

Authors and Affiliations

  1. College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48109, Ann Arbor, Michigan

    Paul K. Wilkinson (Robert Lincoln McNeil Memorial Fellow of the American Foundation for Pharmaceutical Education), Allen J. Sedman, Ermelinda Sakmar, Donald R. Kay & John G. Wagner

  2. School of Pharmacy, Auburn University, 36830, Auburn, Alabama

    Paul K. Wilkinson (Robert Lincoln McNeil Memorial Fellow of the American Foundation for Pharmaceutical Education)

Authors
  1. Paul K. Wilkinson
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  2. Allen J. Sedman
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  3. Ermelinda Sakmar
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  4. Donald R. Kay
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  5. John G. Wagner
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Additional information

Supported by Grant 1ROl AA00683-01A1 from the National Institute on Alcohol Abuse and Alcoholism, Alcohol, Drug Abuse and Mental Health Administration, Rockville, Md.

Abstracted in part from a dissertation by Paul K. Wilkinson, submitted to The University of Michigan in partial fulfillment of the Doctor of Philosophy degree requirements.

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Wilkinson, P.K., Sedman, A.J., Sakmar, E. et al. Pharmacokinetics of ethanol after oral administration in the fasting state. Journal of Pharmacokinetics and Biopharmaceutics 5, 207–224 (1977). https://doi.org/10.1007/BF01065396

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  • DOI: https://doi.org/10.1007/BF01065396

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