Abstract
Auditory brain-stem responses (ABRs) were compared in two groups of multiple sclerosis (MS) patients receiving standard treatment with adrenocorticotropin (ACTH) and with dexamethasone (DEX). ABRs were recorded prior to treatment, on the lst and 8th day of therapy, and 21 days after the hormonal treatment had been discontinued. ABRs in MS patients were within the normal range of variability. Latencies of ABR components increased with increasing rate of presentation, and with decreasing intensity of the click stimuli. Changes in ABRs displayed a consistent pattern in patients treated with ACTH, but showed less coherence after DEX. In ACTH treated patients' latencies of the late ABR waves V and Vn were prolonged after clicks of high intensity, and reduced following clicks of low intensity resulting in a decreased slope of the latency-intensity function of these ABR waves. This pattern became most prominent in the recordings after the treatment had been discontinued, and could reflect an improved transmission across both afferent excitatory and recurrent inhibitory synapses in the auditory pathways. The findings indicate that — besides a common anti-inflammatory action — therapies with ACTH and DEX differ with regard to their influence on central nervous functioning.
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References
Born J, Kern W, Fehm-Wolfsdorf G, Fehm HL (1987) Cortisol effects on attentional processes in man as indicated by event-related potentials. Psychophysiology 24:286–292
Born J, Kern W, Pietrowsky R, Sittig W, Fehm HL (1989) Fragments of ACTH affect electrophysiological signs of controlled stimulus processing in humans. Psychopharmacology 99:439–444
Born J, Schwab R, Pietrowsky R, Pauschinger P, Fehm HL (1989) Glucocorticoid influences on the auditory brain-stem responses in man. Electroencephalogr Clin Neurophysiol 74:209–216
Born J, Seidel E, Pietrowsky R, Fehm HL (1991) Brain evoked responses, a bioassay for central nervous actions of ACTH 1–39 and CRH in humans. Horm Metab Res 23:126–130
Brown JR, Bebe GW, Kurtzke JF, Loewenson RH, Silberberg DH, Tourtellotte WW (1979) The design of clinical studies to assess therapeutic efficacy in multiple sclerosis. Neurology [Suppl] 29:1–23
Buchsbaum MS, Henkin RI (1975) Effects of carbohydrate-active steroids and ACTH on visually-evoked responses in patients with adrenal cortical insufficiency. Neuroendocrinology 19:314–322
DeKloet ER (1991) Brain corticosteroid receptor balance and homeostatic control. Front Neuroendocrinol 12:95–164
Flohr H, Lüneburg U (1982) Effects of ACTH 4–10 on vestibular compensation. Brain Res 248:169–172
Haynes RC, Murad F (1985) Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs: inhibition of adrenocortical steroid biosynthdsis. In: Gilman AG, Goodman LS, Rall TW, Murad F (eds) The pharmacological basis of therapeutics. MacMillan, New York, pp 1459–1489
Landfield PW (1987) Modulation of brain aging correlates by long-term alterations of adrenal steroids and neurally-active peptides. Prog Brain Res 72:279–300
Maida E, Summer K (1979) Serum cortisol levels of multiple sclerosis patients during ACTH treatment. J Neurol 220:143–148
McEwen BS, DeKloet ER, Rostene W (1986) Adrenal steroid receptors and actions in the nervous system. Physiol Rev 66:1121–1188
Milanese C, LaMantia L, Salmaggi A, Campi A, Eoli M, Scaioli V, Nespolo A, Corridori R (1989) Double-blind randomized trial of ACTH versus dexamethasone versus methylprednisolone in multiple sclerosis bouts. Eur Neurol 29:10–14
Pfaff DW, Silva MTA, Weiss J (1971) Telemetered recording of hormone effects on hipnocampal neurons. Science 171:394–395
Pratt H, Bleich N (1982) Auditory brain stem potentials evoked by clicks in notch-filtered masking noise. Electoencephalog Clin Neurophysiol 53:417–426
Pratt H, Sohmer H (1976) Intensity and rate functions of cohlear and brainstem evoked responses to click stimuli in man. Arch Otorhinolaryngol 212:85–92
Robinson K, Rudge P (1977) Abnormalities of the auditory evoked potentials in patients with multiple sclerosis. Brain 100:19–40
Sand T, Sjaastad O, Romslo I, Sulg I (1990) Brain-stem auditory evoked potentials in multiple sclerosis: the relation to VEP, SEP and CSF immunoglobulins. J Neurol 237:376–378
Zöllner C, Karnahl T, Stange G (1976) Input-output function and adaptation behavior of the five early potentials registered with the earlobe-vertex pick-up. Arch Otorhinolaryngol 212:23–33
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Born, J., Schwab, B., Schwab, R. et al. Acute and long-term effects of adrenocorticotropin and dexamethasone on the auditory brainstem response in multiple sclerosis patients. J Neurol 241, 75–80 (1993). https://doi.org/10.1007/BF00869767
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DOI: https://doi.org/10.1007/BF00869767