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A general route for the synthesis of pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine derivatives

Eine allgemeine Synthese von Pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazin-Derivaten

  • Organische Chemie Und Biochemie
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Summary

A facile synthesis of 8-substituted pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazines (6a–i) has been accomplished. The sequence involves the ring closure of a heterocyclic aminonitrile precursor (3) after reaction with (dichloromethylene)-dimethylammonium chloride.

Zusammenfassung

Es wurde ein einfacher Syntheseweg für 8-substituierte Pyrimido[4′,5′:4,5]thieno-[2,3-c]pyridazine entwickelt. Die Reaktion verläuft über den Ringschluß eines heterocyclischen Aminonitrilvorläufers (3) nach Umsetzung mit Dichlormethylen-dimethylammoniumchlorid.

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Authors and Affiliations

  1. Departamento de Química Fundamental e Industrial, Facultad de Ciencias, Universidad de La Coruña, E-15071, La Coruña, Spain

    J. M. Quintela, M. C. Veiga, S. Conde & C. Peinador

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  1. J. M. Quintela
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  2. M. C. Veiga
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  3. S. Conde
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  4. C. Peinador
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Quintela, J.M., Veiga, M.C., Conde, S. et al. A general route for the synthesis of pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine derivatives. Monatsh Chem 127, 739–745 (1996). https://doi.org/10.1007/BF00817265

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  • DOI: https://doi.org/10.1007/BF00817265

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